Fluorescence lifetime imaging microscopy (FLIM) has been rapidly developed over the past
30 years and widely applied in biomedical engineering. Recent progress in fluorophore …

Fluorescence lifetime imaging microscopy (FLIM) is increasingly used in biomedicine,
material science, chemistry, and other related research fields, because of its advantages of …

Time-correlated single photon counting (TCSPC) was born 54 years ago, in 1960, when
Bollinger and Thomas published a paper on the 'Measurement of Time Dependence of …

Potentially premalignant oral epithelial lesions (PPOELs) are a group of clinically suspicious
conditions, of which a small percentage will undergo malignant transformation. PPOELs are …

Abstract While NAD (P) H fluorescence lifetime imaging (FLIM) can detect changes in flux
through the TCA cycle and electron transport chain (ETC), it remains unclear whether NAD …

Fluorescence lifetime imaging (FLIm) is an optical spectroscopic imaging technique capable
of real‐time assessments of tissue properties in clinical settings. Label‐free FLIm is sensitive …

Simple Summary Complete resection of dysplastic and malignant tissue improves overall
survival and delays cancer recurrence in oral cancer patients; however, intraoperative …

Early-stage diagnosis is a crucial step in reducing the mortality rate in oral cancer cases.
Point-of-care (POC) devices for oral cancer diagnosis hold great future potential in …

Autofluorescence spectroscopy has emerged in recent years as a powerful tool to report
label-free contrast between normal and diseased tissues, both in vivo and ex vivo. We report …

Introduction Incomplete head and neck cancer resection occurs in up to 85% of cases,
leading to increased odds of local recurrence and regional metastases; thus, image-guided …