The tachykinins, exemplified by substance P, are one of the most intensively studied
neuropeptide families. They comprise a series of structurally related peptides that derive …

The microbiota-gut-brain axis or simple gut-brain axis (GBA) is a complex and interactive
bidirectional communication network linking the gut to the brain. Alterations in the …

Covers all aspects of the structure, function, neurochemistry, transmitter identification and
development of the enteric nervous system This book brings together extensive knowledge …

Prolonged unaccustomed exercise involving muscle lengthening (eccentric) actions can
result in ultrastructural muscle disruption, impaired excitation–contraction coupling …

The neurokinin 1 receptor (NK‐1R) is the main receptor for the tachykinin family of peptides.
Substance P (SP) is the major mammalian ligand and the one with the highest affinity. SP is …

Background and aims: The role of sensory neurones in colitis was studied by chemical
denervation of primary sensory neurones as well as antagonism of the vanilloid receptor-1 …

Neuroplastic changes in the enteric nervous system (ENS) may be observed in
physiological states, such as development and aging, or occur as a consequence of different …

Transient Receptor Potential Ankyrin 1 (TRPA1) channels are localized on sensory nerves
and several non-neural cells, but data on their functional significance are contradictory. We …

OBJECTIVES: Low-grade colonic mucosal inflammation has been postulated to have an
important role in the pathophysiology of irritable bowel syndrome (IBS). The objectives of …

Background & Aims Tachykinins are involved in physiological and pathophysiological
mechanisms in the gastrointestinal tract. The major sources of tachykinins in the gut are …