The histone deacetylase (HDAC) enzymes, a class of epigenetic regulators, are historically
well established as attractive therapeutic targets. During investigation of trends within …

Oncolytic viruses (OVs) are a new class of cancer therapeutics. This review was undertaken
to provide insight into the current landscape of OV clinical trials. A PubMed search identified …

HIV-1-infected cells that persist despite antiretroviral therapy (ART) are frequently
considered" transcriptionally silent," but active viral gene expression may occur in some …

Attempts to reduce the human immunodeficiency virus type 1 (HIV-1) reservoir and induce
antiretroviral therapy (ART)-free virologic control have largely been unsuccessful. In this …

Inducing antiretroviral therapy (ART)-free virological control is a critical step toward a human
immunodeficiency virus type 1 (HIV-1) cure. In this phase 2a, placebo-controlled, double …

Biomarker discovery and validation are necessary for improving the prediction of clinical
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …

Adaptive immunity, orchestrated by B-cells and T-cells, plays a crucial role in protecting the
body from pathogenic invaders and can be used as tools to enhance the body's defense …

Long-lasting, latently infected resting CD4+ T cells are the greatest obstacle to obtaining a
cure for HIV infection, as these cells can persist despite decades of treatment with …

The main barrier to HIV cure is a persistent reservoir of latently infected CD4+ T cells
harboring replication-competent provirus that fuels rebound viremia upon antiretroviral …

Indoles constitute extensively explored heterocyclic ring systems with wide range of
applications in pathophysiological conditions that is, cancer, microbial and viral infections …