Epigenetics has the potential to explain various biological phenomena that have heretofore
defied complete explication. This review describes the various types of endogenous human …

The formation of the embryonic brain and spinal cord begins as the neural plate bends to
form the neural folds, which meet and adhere to close the neural tube. The neural ectoderm …

Iron deficiency (ID) before the age of 3 y can lead to long-term neurological deficits despite
prompt diagnosis of ID anemia (IDA) by screening of hemoglobin concentrations followed by …

Increasing evidence points to a complex interplay between genes and the environment in
autism spectrum disorder (ASD), including rare de novo mutations in chromatin genes such …

Maternal exposure to dietary factors during pregnancy can influence embryonic
development and may modulate the phenotype of offspring through epigenetic …

STUDY QUESTION Do paternal exposures to folic acid deficient (FD), and/or folic acid
supplemented (FS) diets, throughout germ cell development adversely affect male germ …

Rapidly growing evidences link maternal lifestyle and prenatal factors with serious health
consequences and diseases later in life. Extensive epidemiological studies have identified a …

Background We previously showed that continued folic acid (FA) supplementation beyond
the first trimester of pregnancy appears to have beneficial effects on neurocognitive …

Brain development is a life-long process that encompasses several critical periods of
transition, during which significant cognitive changes occur. Embryonic development …

Methylenetetrahydrofolate reductase (MTHFR) generates methyltetrahydrofolate for
methylation reactions. Severe MTHFR deficiency results in homocystinuria and neurologic …