Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation

Y Jiang, Y Chen, Z Song, Z Tan, J Cheng - Advanced Drug Delivery …, 2021 - Elsevier
The recent outbreaks of infectious diseases caused by multidrug-resistant pathogens have
sounded a piercing alarm for the need of new effective antimicrobial agents to guard public …

Antimicrobial drugs bearing guanidine moieties: A review

SH Kim, D Semenya, D Castagnolo - European Journal of Medicinal …, 2021 - Elsevier
Compounds incorporating guanidine moieties constitute a versatile class of biologically
interesting molecules with a wide array of applications. As such, guanidines have been …

Low-drug resistance carbon quantum dots decorated injectable self-healing hydrogel with potent antibiofilm property and cutaneous wound healing

P Li, S Liu, X Yang, S Du, W Tang, W Cao… - Chemical Engineering …, 2021 - Elsevier
Local bacterial infection remains an increasingly severe threat to human health worldwide,
and infection control is still a challenging task in clinics. Systemic administration of …

[HTML][HTML] Synthetic and natural guanidine derivatives as antitumor and antimicrobial agents: A review

AR Gomes, CL Varela, AS Pires… - Bioorganic …, 2023 - Elsevier
Guanidines are fascinating small nitrogen-rich organic compounds, which have been
frequently associated with a wide range of biological activities. This is mainly due to their …

Low-toxicity carbon quantum dots derived from gentamicin sulfate to combat antibiotic resistance and eradicate mature biofilms

P Li, S Liu, W Cao, G Zhang, X Yang, X Gong… - Chemical …, 2020 - pubs.rsc.org
Carbon quantum dots derived from gentamicin sulfate are directly developed by facile
calcination at different temperatures. A promising nanomaterial, CQD180, even shows a …

Small molecular mimetics of antimicrobial peptides as a promising therapy to combat bacterial resistance

P Teng, H Shao, B Huang, J Xie, S Cui… - Journal of Medicinal …, 2023 - ACS Publications
Clinically, antibiotics are widely used to treat infectious diseases; however, excessive drug
abuse and overuse exacerbate the prevalence of drug-resistant bacterial pathogens …

Battle against vancomycin-resistant bacteria: recent developments in chemical strategies

G Dhanda, P Sarkar, S Samaddar… - Journal of medicinal …, 2018 - ACS Publications
Vancomycin, a natural glycopeptide antibiotic, was used as the antibiotic of last resort for the
treatment of multidrug-resistant Gram-positive bacterial infections. However, almost 30 years …

Development of bis-cyclic imidazolidine-4-one derivatives as potent antibacterial agents

M Wang, R Gao, M Zheng, P Sang, C Li… - Journal of medicinal …, 2020 - ACS Publications
Antibiotic resistance has emerged as one of the biggest public health concerns all over the
world. In an effort to combat bacterial infections, a series of imidazolidine-4-one derivatives …

Antimicrobial peptide mimics for clinical use: does size matter?

J Svenson, N Molchanova, CI Schroeder - Frontiers in Immunology, 2022 - frontiersin.org
The search for efficient antimicrobial therapies that can alleviate suffering caused by
infections from resistant bacteria is more urgent than ever before. Infections caused by multi …

N-Arylimidazoliums as Highly Selective Biomimetic Antimicrobial Agents

Q Kong, G Li, F Zhang, T Yu, X Chen… - Journal of Medicinal …, 2022 - ACS Publications
Antibiotic resistance has become one of the greatest health threats in the world. In this study,
a charge-dispersed dimerization strategy is described for the antimicrobial peptide (AMP) …