Combined with TCR stimuli, extracellular cytokine signals initiate the differentiation of naive
CD 4+ T cells into specialized effector T‐helper (Th) and regulatory T (Treg) cell subsets …

IL-4 was first identified as a T cell-derived growth factor for B cells. Studies over the past
several decades have markedly expanded our understanding of its cellular sources and …

CD4+ T helper (TH) cells and regulatory T (Treg) cells that respond to common allergens
play an important role in driving and dampening airway inflammation in patients with …

Regulatory T cells (Treg cells) are essential for self-tolerance and immune homeostasis.
Lack of effector T cell (Teff cell) function and gain of suppressive activity by Treg cells are …

The transcriptional repressor Bcl6 is a critical regulator of T helper cell fate, and inhibits Th2-
type inflammation. We have found that microRNA-21 (miR-21) is a novel target gene for Bcl6 …

Background Special AT‐rich binding protein‐1 (SATB 1) reprograms chromatin organization
and transcription profiles to promote tumour growth and metastasis. Aims This study aimed …

SATB (Special AT-rich binding protein) family proteins have emerged as key regulators that
integrate higher-order chromatin organization with the regulation of gene expression …

Deficient expression of SATB1 hampers thymocyte development and results in inept T-cell
lineages. Recent data implicate dysregulated SATB1 expression in the pathogenesis of …

Regulatory T cells (Tregs) are central in controlling immune responses, and dysregulation of
their function can lead to autoimmune disorders or cancer. Despite extensive studies on …

CUT homeobox genes represent a captivating gene class fulfilling critical functions in the
development and maintenance of multiple cell types across a wide range of organisms …