Since the discoveries that have verified nitric oxide (NO) as an endogenously produced cell
signaling molecule, research surrounding its production and mechanisms of action have …

Trophic factors are endogenously secreted proteins that act in an autocrine and/or paracrine
fashion to affect vital cellular processes such as proliferation, differentiation, and …

The existence of protective mechanisms in the adult brain is gradually being recognized as
an important aspect of brain function. For many years, self-repair processes in the post …

Sensory organs represent the interface between the central nervous system of organisms
and the environment in which they live. To date, we still lack a true integration of ecological …

Insulin-like growth factor-1 (IGF-1) plays a key role in synaptic plasticity, spatial learning, and
anxiety-like behavioral processes. While IGF-1 regulates neuronal firing and synaptic …

Hyperpolarization-activated cyclic nucleotide-gated channels (HCN1-4) play a crucial role in
the regulation of cell excitability. Importantly, they contribute to spontaneous rhythmic activity …

purpose. To examine insulin-like growth factor (IGF)-1 stimulation of expression of hypoxia
inducible factor (HIF)-1α and secretion of vascular endothelial growth factor (VEGF) and IGF …

After decades of research in the neurobiology of IGF-I, its role as a prototypical neurotrophic
factor is undisputed. However, many of its actions in the adult brain indicate that this growth …

On systemic injection, insulin-like growth factor I (IGF-I) elicits a prolonged increase in the
excitability of dorsal column nuclei (DCN) cells in the brain stem as well as other target …

Protein-tyrosine phosphatase receptor type G (RPTPγ/PTPRG) interacts in vitro with
contactin-3–6 (CNTN3–6), a group of glycophosphatidylinositol-anchored cell adhesion …