The hypothalamic-pituitary-adrenal (HPA) axis is involved in the pathophysiology of many
neuropsychiatric disorders. Increased HPA axis activity can be observed during chronic …

Preterm birth which occurs before 37 weeks gestation is one of the most common obstetrical
complication in humans. After many studies, it appears that “not one answer fits all” …

Progesterone acts through the progesterone receptor to direct physiological adaption of the
uterus in preparation and completion of pregnancy. Genome-wide transcriptome and …

The steroid hormones progesterone (P4) and estradiol-17β (E2), produced by the placenta
in humans and the ovaries in rodents, serve crucial roles in the maintenance of pregnancy …

The “ovarian cycle” is an exquisite and dynamic endocrine system that includes ovarian
events, hypothalamic–pituitary interactions, uterine endometrial and myometrial changes …

Postpartum depression (PPD) affects up to 20% of mothers and has negative consequences
for both mother and child. Although exposure to psychosocial stress during pregnancy and …

Uterine contractile dysfunction leads to pregnancy complications such as preterm birth and
labor dystocia. In humans, it is hypothesized that progesterone receptor isoform PGR-B …

Myometrium holds the structural integrity for the uterus and generates force for parturition
with its primary component, the smooth muscle cells. The progesterone receptor mediates …

The steroid hormone progesterone (P4), acting via the nuclear P4 receptors (PRs) in uterine
cells, is essential for the establishment and maintenance of pregnancy. P4/PR signaling …

Historically, studies on the endocrinology of pregnancy and parturition in horses have made
major contributions of relevance to mammals in general. Recent use of liquid …