Malaria has been a human health concern ever since the dawn of mankind, but despite the
huge struggles made to date to fight this infection, in 2012 over half a million people were …

Significance: Parasitic diseases affect hundreds of millions of people worldwide and
represent major health problems. Treatment is becoming extremely difficult due to the …

Our work on targeting redox equilibria of malarial parasites propagating in red blood cells
has led to the selection of six 1, 4-naphthoquinones, which are active at nanomolar …

There is a pressing need for compounds with broad-spectrum activity against malaria
parasites at various life cycle stages to achieve malaria elimination. However, this goal …

The homodimeric flavoenzyme glutathione reductase catalyzes NADPH-dependent
glutathione disulfide reduction. This reaction is important for keeping the redox homeostasis …

New hydrogen bonded charge transfer complex (HBCT) between 2, 4-diamino-quinoline-3-
carbonitrile (DAQC) and chloranilic acid (CA) is synthesized and characterized …

Simple and halide-atom economical HX reagents (X= Cl, Br and I) were applied to the
remote Csingle bondH bond halogenation reaction of 8-aminoquinoline amides. This …

A mild and efficient functionalization of 8‐aminoquinolines has been demonstrated through
the acylation and regioselective C5‐H halogenation in one pot under transition metal free …

The role of the amino group in the excited-state dynamics of 3-aminoquinoline (3AQ) has
been investigated by comparison with its synthetic derivative 3-(piperidin-1-yl) quinoline …

The effect of an exocyclic substituent on the ionization potential of primaquine, an important
antimalarial drug, was investigated using density functional theory methods. It was found …