CRISPR/Cas9 gene editing technology has taken the scientific community by storm since its
development in 2012. First discovered in 1987, CRISPR/Cas systems act as an adaptive …

Plant microbiomes are not only diverse, but also appear to host a vast pool of secondary
metabolites holding great promise for bioactive natural products and drug discovery. Yet …

Background The broad host range pathogen Sclerotinia sclerotiorum infects over 400 plant
species and causes substantial yield losses in crops worldwide. Secondary metabolites are …

Trichophyton rubrum is the most common fungal pathogen in the world, which has been
studied as an important dermatophyte model organism. Despite the prevalence of T. rubrum …

The Ascomycete Ophiostoma novo-ulmi threatens elm populations worldwide. The
molecular mechanisms underlying its pathogenicity and virulence are still largely …

The fungus Metarhizium anisopliae is a facultative insect pathogen used as biological
control agent of several agricultural pests worldwide. It is a dimorphic fungus that is able to …

Forests provide invaluable economic, ecological, and social services. At the same time, they
are exposed to several threats, such as fragmentation, changing climatic conditions, or …

Abstract Clethramycin (1) and mediomycin A (2) belong to the linear polyene polyketide
(LPP) family of antibiotics that exhibit potent antifungal activity. Structural similarities exist …

Raffaelea lauricola is an invasive fungal pathogen and symbiont of the redbay ambrosia
beetle (Xyleborus glabratus) that has caused widespread mortality to redbay (Persea …

Fungi are renowned producers of natural compounds, also known as secondary metabolites
(SMs) that display a wide array of biological activities. Typically, the genes that are involved …