Over the past 15 years, rapid progress has been made in developmental therapeutics,
especially regarding the use of matched targeted therapies against specific oncogenic …

We investigated the challenges of conducting IMPACT2, an ongoing randomized study that
evaluates molecular testing and targeted therapy (ClinicalTrials. gov: NCT02152254) …

PURPOSE Clinical trials of novel and targeted agents increasingly require biomarkers for
eligibility. Precision oncology continues to evolve, but challenges hamper broad use of …

PURPOSE The My Cancer Genome (MCG) knowledgebase and resulting website were
launched in 2011 with the purpose of guiding clinicians in the application of genomic testing …

Background Precision oncology relies on molecular diagnostics, and the value-proposition
of modern healthcare networks promises a higher standard of care across partner sites. We …

Extraordinary advances in cancer screening, therapeutics, and supportive care have
contributed to substantial progress in survival rates among patients with cancer over the last …

By establishing omics sequencing of patient tumors as a crucial element in cancer treatment,
the extensive implementation of precision oncology necessitates effective and prompt …

Introduction The oncology clinical trial recruitment process is time, labor, and resource
intensive, and poor accrual rates are common. We describe the VA Connecticut Cancer …

PURPOSE To evaluate natural language processing (NLP) methods to infer metastatic sites
from radiology reports. METHODS A set of 4,522 computed tomography (CT) reports of 550 …

Introduction: Clinical trials are essential to the advancement of clinical therapies that
improve the outcomes of people with cancer. However, enrollment in clinical trials remains a …