Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide,
leading to a large global cancer burden. Hepatocyte growth factor (HGF) and its high-affinity …

Although fibroblast growth factors are potent angiogenic factors, they may indirectly control
neovascularization in concert with other growth factors. Thus, the unique role played by …

Cancers are believed to arise from cancer stem cells (CSCs), but it is not known if these cells
remain dependent upon the niche microenvironments that regulate normal stem cells. We …

Formation of new blood vessels (angiogenesis) has been demonstrated to be a basic
prerequisite for sustainable growth and proliferation of tumor. Several growth factors …

The Met receptor tyrosine kinase (RTK) is an attractive oncology therapeutic target. Met and
its ligand, HGF, play a central role in signaling pathways that are exploited during the …

Recurrent/metastatic head and neck cancer remains a devastating disease with insufficient
treatment options. We investigated the MET receptor tyrosine kinase as a novel target for the …

Intracellular signaling is mediated by reversible posttranslational modifications (PTMs) that
include phosphorylation, ubiquitination, and acetylation, among others. In response to …

Abstract MNNG HOS transforming gene (MET) is a class IV receptor tyrosine kinase,
expressed on the surface of epithelial cells. The interaction with the hepatocyte grow factor …

Hepatocyte growth factor plays multiple roles in cancer, by acting as a motility and invasion
stimulating factor, promoting metastasis and tumour growth. Furthermore, it acts as a …

To explore the in vivo significance of ShcA during mammary tumorigenesis, we used mice
expressing several phosphotyrosine‐deficient ShcA alleles under the control of their …