Children with Down syndrome (DS, trisomy 21) are at a significantly higher risk of
developing acute leukemia compared to the overall population. Many studies investigating …

Children with Down syndrome (DS) have a 10-to 20-fold greater predisposition to develop
acute leukemia compared to the general population, with a skew towards myeloid leukemia …

DYRK1A is a serine/threonine kinase encoded on human chromosome 21 (HSA21) that has
been implicated in several pathologies of Down syndrome (DS), including cognitive deficits …

Abstract CRLF2-rearranged (CRLF2 r) acute lymphoblastic leukemia (ALL) accounts for
more than half of Philadelphia chromosome-like (Ph-like) ALL and is associated with a poor …

Pediatric patients with recurrent and refractory cancers are in most need for new treatments.
This study developed patient-derived-xenograft (PDX) models within the European …

Despite significant advances, outcomes for children with Down syndrome (DS, trisomy 21)
who develop acute lymphoblastic leukemia (ALL) remain poor. Reports of large DSALL …

Mutations of ion channels and G-protein-coupled receptors (GPCRs) are not uncommon and
can lead to cardiovascular diseases. Given previously reported multiple factors associated …

Background: Abnormal redox equilibrium is a major contributor to tumor malignancy and
treatment resistance. Understanding reactive oxygen species (ROS) metabolism is a key to …

Prenatal trisomy 21 (T21) screening commonly involves testing a maternal blood sample for
fetal DNA aneuploidy. It is reliable but poses a cost barrier to universal screening. We …

Copy number alterations (CNAs), resulting from the gain or loss of genetic material from as
little as 50 base pairs or as big as entire chromosome (s), have been associated with many …