Perspectives and controversies regarding the use of natural products for the treatment of lung cancer

T Wen, L Song, S Hua - Cancer Medicine, 2021 - Wiley Online Library
Lung cancer is the leading cause of cancer‐related mortality both in men and women and
accounts for 18.4% of all cancer‐related deaths. Although advanced therapy methods have …

Inflammation and oxidative stress in snakebite envenomation: a brief descriptive review and clinical implications

D Resiere, H Mehdaoui, R Neviere - Toxins, 2022 - mdpi.com
Snakebite envenoming is a pathological condition which may occur in response to the
injection of venom. Snake venoms contain a complex mixture of biologically active …

Snake venom phospholipase A2s exhibit strong virucidal activity against SARS-CoV-2 and inhibit the viral spike glycoprotein interaction with ACE2

AE Siniavin, MA Streltsova, MA Nikiforova… - Cellular and Molecular …, 2021 - Springer
The COVID-19 pandemic caused by SARS-CoV-2 requires new treatments both to alleviate
the symptoms and to prevent the spread of this disease. Previous studies demonstrated …

Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib

KE Bartlett, SR Hall, SA Rasmussen… - Proceedings of the …, 2024 - National Acad Sciences
Snakebite envenoming is a neglected tropical disease that causes substantial mortality and
morbidity globally. The venom of African spitting cobras often causes permanent injury via …

Animal protein toxins: origins and therapeutic applications

N Chen, S Xu, Y Zhang, F Wang - Biophysics reports, 2018 - Springer
Venomous animals on the earth have been found to be valuable resources for the
development of therapeutics. Enzymatic and non-enzymatic proteins and peptides are the …

Chikungunya virus entry is strongly inhibited by phospholipase A2 isolated from the venom of Crotalus durissus terrificus

IA Santos, JF Shimizu, DM de Oliveira, DOS Martins… - Scientific Reports, 2021 - nature.com
Chikungunya virus (CHIKV) is the etiologic agent of Chikungunya fever, a globally
spreading mosquito-borne disease. There is no approved antiviral or vaccine against …

Snake venom toxins: Potential anticancer therapeutics

BC Offor, LA Piater - Journal of Applied Toxicology, 2024 - Wiley Online Library
Snake venom contains a cocktail of compounds dominated by proteins and peptides, which
make up the toxin. The toxin components of snake venom attack several targets in the …

[HTML][HTML] Effects of animal venoms and toxins on hallmarks of cancer

J Chaisakul, WC Hodgson, S Kuruppu… - Journal of …, 2016 - ncbi.nlm.nih.gov
Animal venoms are a cocktail of proteins and peptides, targeting vital physiological
processes. Venoms have evolved to assist in the capture and digestion of prey. Key venom …

Therapeutic applications of snake venoms: An invaluable potential of new drug candidates

R Diniz-Sousa, CAS Caldeira, SS Pereira… - International Journal of …, 2023 - Elsevier
Animal venoms and their chemical compounds have aroused both empirical and scientific
attention for ages. However, there has been a significant increase in scientific investigations …

Why to study peptides from venomous and poisonous animals?

AN de Oliveira, AM Soares, SL Da Silva - International Journal of Peptide …, 2023 - Springer
Venom and poison peptides are powerful biological weapons and have proven immense
pharmacological potential because of their high binding affinity to a wide range of molecular …