Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+] i).
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …

Calcium is thought to play an important role in regulating mitochondrial function. Evidence
suggests that an increase in mitochondrial calcium can augment ATP production by altering …

The major physiological stimulus for the secretion of insulin from the pancreatic β-cell is an
increase in the plasma glucose concentration. It is well established that glucose-stimulated …

INTRODUCTION of Ca2+ indicators (photoproteins, fluorescent dyes) that can be trapped in
the cytosolic compartment of living cells has yielded major advances in our knowledge of …

The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

The relation between muscle length or sarcomere length and developed tension for lengths
up to the optimal for contraction (L max) is much steeper in cardiac muscle than in skeletal …

1. The calcium‐sensitive photoprotein aequorin was micro‐injected into cells of rat and cat
ventricular muscles. The resulting light emission is a function of intracellular free calcium …

This book provides the reader with an account of some of the experimental evidence on
which our present knowledge is based. The third edition of this highly successful book has …

Tobacco (Nicotiana plumbaginifolia) seedlings genetically transformed to express
apoaequorin were incubated in h-coelenterazine to reconstitute the calcium-sensitive …

Targeted recombinant aequorins represent to date the most specific means of monitoring
[Ca 2+] in subcellular organelles (Rizzuto, R., Simpson, AWM, Brini, M., and Pozzan …