The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …

In addition to constituting the genetic material of an organism, DNA is a tracer for the
recognition of foreign pathogens and a trigger of the innate immune system. cGAS functions …

Genomic instability is an important driver of ageing. The accumulation of DNA damage is
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …

Abstract Cyclic GMP–AMP synthase (cGAS) is an innate immune sensor for cytosolic
microbial DNA. After binding DNA, cGAS synthesizes the messenger 2′ 3′-cyclic GMP …

The recognition of microbial nucleic acids is a major mechanism by which the immune
system detects pathogens. Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA …

Detection of microbial DNA is an evolutionarily conserved mechanism that alerts the host
immune system to mount a defense response to microbial infections. However, this detection …

The rapid detection of microbial agents is essential for the effective initiation of host defence
mechanisms against infection. Understanding how cells detect cytosolic DNA to trigger …

Cells are equipped with numerous sensors that recognize nucleic acids, which probably
evolved for defence against viruses. Once triggered, these sensors stimulate the production …

Cytosolic DNA arising from intracellular pathogens triggers a powerful innate immune
response,. It is sensed by cyclic GMP–AMP synthase (cGAS), which elicits the production of …