Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

The loss of vital cells within healthy tissues contributes to the development, progression and
treatment outcomes of many human disorders, including neurological and infectious …

Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

In the cerebral cortex, GABAergic interneurons have evolved as a highly heterogeneous
collection of cell types that are characterized by their unique spatial and temporal …

Cell death is prevalent throughout life; however, the coordinated interactions and roles of
phagocytes during corpse removal in the live brain are poorly understood. We developed …

GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of
exciting new discoveries provides compelling evidence that disruptions in a number of key …

The central nervous system (CNS) and the immune system are both intricate and highly
organized systems that regulate the entire body, with both sharing certain common features …

Complex neuronal circuitries such as those found in the mammalian cerebral cortex have
evolved as balanced networks of excitatory and inhibitory neurons. Although the …

The proper construction of neural circuits requires the generation of diverse cell types, their
distribution to defined regions, and their specific and appropriate wiring. A major objective in …

Directed differentiation from human pluripotent stem cells (hPSCs) has seen significant
progress in recent years. However, most differentiated populations exhibit immature …