It has been approximately a decade since telomerase was described as an almost universal
marker for human cancer. Most human tumours not only express telomerase but also have …

Cancer remains one of the leading causes of death worldwide. Conventional therapeutic
strategies usually offer limited specificity, resulting in severe side effects and toxicity to …

Hepatocellular carcinoma (HCC) develops predominantly in the inflammatory environment
of a cirrhotic liver caused by hepatitis, toxin exposure, or chronic liver disease. A targeted …

The extremities of eukaryotic chromosomes are called telomeres. They have a structure
unlike the bulk of the chromosome, which allows the cell DNA repair machinery to …

The continuous growth of advanced malignancies almost universally correlates with the
reactivation of telomerase. While there is still a great deal of basic and applied research to …

Purpose: Replication-selective tumor-specific viruses present a novel approach for treating
neoplastic disease. These vectors are designed to induce virus-mediated lysis of tumor cells …

Protein toxins confer a defense against predation/grazing or a superior pathogenic
competence upon the producing organism. Such toxins have been perfected through …

The catalytic component of human telomerase reverse transcriptase (hTERT) is not
expressed in most primary somatic human cells, whereas the majority of cancer cells …

Specialized nucleoprotein structures, termed telomeres, cap the ends of human
chromosomes. These terminal structures, composed of repetitive arrays of guanine-rich …

Cancer gene therapy has been one of the most exciting areas of therapeutic research in the
past decade. In this review, we discuss strategies to restrict transcription of transgenes to …