The sensory, associative and limbic neocortical structures play a critical role in shaping
incoming noxious inputs to generate variable pain perceptions. Technological advances in …

The locus coeruleus (LC)-noradrenergic system is the main source of noradrenaline in the
central nervous system and is involved intensively in modulating pain and stress-related …

Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …

Background Chronic pain is often accompanied by short-term memory deficit and
depression. Currently, it is believed that short-term memory deficit and depression are …

Pain is a multidimensional experience and negative affect, or how much the pain is
“bothersome”, significantly impacts the sufferers' quality of life. It is well established that the κ …

Background: One in five individuals live with chronic pain globally, which often co-occurs
with sleep problems, anxiety, depression, and substance use disorders. Although these …

Long-COVID, or the persistence of COVID-19 symptoms for months after initial infection, has
been shown to impact the lives of those affected. The current study sought to investigate the …

Stress has been consistently linked to negative impacts on physical and mental health. More
specifically, patients with chronic pain experience stress intolerance, which is an …

Spinal cord injury (SCI) leads to increased anxiety and depression in as many as 60% of
patients. Yet, despite extensive clinical research focused on understanding the variables …

Previous studies have demonstrated improvements in pain following short-term medical
cannabis (MC) use, suggesting long-term MC treatment may alleviate symptoms associated …