The bacterial superantigen and superantigen‐like proteins

JD Fraser, T Proft - Immunological reviews, 2008 - Wiley Online Library
The bacterial superantigens are protein toxins that bind to major histocompatibility complex
class II and T‐cell receptor to stimulate large numbers of T cells. The majority are produced …

Superantigens: microbial agents that corrupt immunity

M Llewelyn, J Cohen - The Lancet infectious diseases, 2002 - thelancet.com
Microbial Superantigens are a family of protein exotoxins that share the ability to trigger
excessive and aberrant activation of T cells. The best characterised are the staphylococcal …

Community-acquired methicillin-resistant Staphylococcus aureus: community transmission, pathogenesis, and drug resistance

T Yamamoto, A Nishiyama, T Takano, S Yabe… - Journal of Infection and …, 2010 - Springer
Methicillin-resistant Staphylococcus aureus (MRSA) is able to persist not only in hospitals
(with a high level of antimicrobial agent use) but also in the community (with a low level of …

Understanding mechanisms of virulence in MRSA: implications for antivirulence treatment strategies

RC Hsieh, R Liu, DJ Burgin, M Otto - Expert Review of Anti-infective …, 2023 - Taylor & Francis
ABSTRACT Introduction Methicillin-resistant Staphylococcus aureus (MRSA) is a
widespread pathogen, often causing recurrent and deadly infections in the hospital and …

Superantigens: structure-function relationships

MD Baker, KR Acharya - International Journal of Medical Microbiology, 2004 - Elsevier
Superantigens are a class of highly potent immuno-stimulatory molecules produced by
Staphylococcus aureus and Streptococcus pyogenes. These toxins possess the unique …

Microbial superantigens: from structure to function

AC Papageorgiou, KR Acharya - Trends in microbiology, 2000 - cell.com
Superantigens are highly potent immune stimulators with a unique ability to interact
simultaneously with MHC class II molecules and T cell receptors, forming a trimolecular …

[HTML][HTML] Streptococcal superantigens: biological properties and potential role in disease

T Proft, JD Fraser - 2016 - europepmc.org
Superantigens (SAgs) are a family of highly potent mitogens that share the ability to trigger
excessive stimulation of human and other mammalian T lymphocytes. This leads to a …

[HTML][HTML] Streptococcus pyogenes Superantigens: Biological properties and potential role in disease

T Proft, JD Fraser - … Basic Biology to Clinical Manifestations [Internet …, 2022 - ncbi.nlm.nih.gov
Superantigens (SAgs) are a family of highly potent mitogens that share the ability to trigger
excessive stimulation of human and other mammalian T lymphocytes. This leads to a …

Healthcare- and Community-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) and Fatal Pneumonia with Pediatric Deaths in Krasnoyarsk, Siberian …

OE Khokhlova, WC Hung, TW Wan, Y Iwao, T Takano… - PLoS …, 2015 - journals.plos.org
Methicillin-resistant Staphylococcus aureus (MRSA) is a common multidrug-resistant (MDR)
pathogen. We herein discussed MRSA and its infections in Krasnoyarsk, Siberian Russia …

The three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome

VL Arcus, R Langley, T Proft, JD Fraser… - Journal of Biological …, 2002 - ASBMB
The staphylococcal enterotoxin-like toxins (SETs) are a family of proteins encoded within the
Staphylococcus aureus genome that were identified by their similarity to the well described …