Although advances in preventive medicine have greatly improved prognosis, cardiovascular
disease (CVD) remains the leading cause of death worldwide. This clearly indicates that …

Natural killer (NK) cell‐mediated cytotoxicity is governed by the formation of a lytic immune
synapse in discrete regulated steps, which give rise to an extensive array of cellular …

Mucosal-associated invariant T (MAIT) cells are an innate-like T-cell population restricted by
the non-polymorphic, major histocompatibility complex class I-related protein 1, MR1. MAIT …

Purpose: Innate immunity is an indispensable arm of tumor immune surveillance, and the
liver is an organ with a predominance of innate immunity, where mucosal-associated …

Many immune correlates of CD8+ T-cell-mediated control of HIV replication, including
polyfunctionality, proliferative ability, and inhibitory receptor expression, have been …

Background. The novel influenza vaccine MVA-NP+ M1 is designed to boost cross-reactive
T-cell responses to internal antigens of the influenza A virus that are conserved across all …

Immunotherapy is a curable treatment for certain cancers, but it is still only effective in a
small subset of patients. We have recently reported that programmed cell death protein-1 …

Secretory lysosomes of natural killer (NK) cells, containing perforin and granzymes, are
indispensable for NK-cell cytotoxicity because their release results in the induction of target …

There are many different cells in the immune system. To mount an effective immune
response, they need to communicate with each other. One way in which this is done is by …

In mice, two T-box transcription factors, T-box expressed in T cells (T-bet) and
eomesodermin (Eomes), drive the differentiation of CD8 T cell lineages; however, little is …