Accumulating evidence shows that despite clonal origins tumors eventually become
complex communities comprised of phenotypically distinct cell subpopulations. This …

Mitochondria are essential organelles that play critical roles in energy metabolism,
apoptosis and various cellular processes. Accumulating evidence suggests that …

EWS/FLI is the defining mutation of Ewing sarcoma. This oncogene drives malignant
transformation and progression and occurs in a genetic background characterized by few …

Primary bone sarcomas, including osteosarcoma (OS) and Ewing sarcoma (ES), are
aggressive tumors with peak incidence in childhood and adolescence. The intense standard …

Simple Summary EWS-based fusions are aberrantly fused genes that drive Ewing sarcoma
and desmoplastic small round cell tumor (DSRCT). Fusion data may be useful for …

Abstract Purpose: Propagation of Ewing sarcoma requires precise regulation of EWS:: FLI1
transcriptional activity. Determining the mechanisms of fusion regulation will advance our …

Oncogenic fusion proteins display exquisite tissue specificity, revealing that malignant
transformation requires cooperation with cell-autonomous factors. Recent studies have also …

Ewing sarcoma is an aggressive pediatric bone and soft tissue tumor, most commonly driven
by EWS-FLI1. The standard of care for Ewing sarcoma has not improved in decades, and by …