Picolinic Acid is an endogenous metabolite of L-tryptophan (TRP) that has been reported to
possess a wide range of neuroprotective, immunological, and anti-proliferative affects within …

The kynurenine pathway generates multiple tryptophan metabolites called collectively
kynurenines and leads to formation of the enzyme cofactor nicotinamide adenine …

Nicotinamide N-methyltransferase (NNMT) is overexpressed in a variety of human cancers,
where it contributes to tumorigenesis by a mechanism that is still poorly understood. Here …

Activation of the kynurenine pathway (KP) of tryptophan metabolism results from chronic
inflammation and is known to exacerbate progression of neurodegenerative disease. To …

The Saccharomyces cerevisiae Sir2 protein is an NAD+-dependent histone deacetylase that
plays a critical role in transcriptional silencing, genome stability, and longevity. A human …

Background Patients with depression and suicidality suffer from low-grade
neuroinflammation. Pro-inflammatory cytokines activate indoleamine 2, 3-dioxygenase, an …

The NMDA-receptor antagonist ketamine has proven efficient in reducing symptoms of
suicidality, although the mechanisms explaining this effect have not been detailed in …

There is good evidence that the kynurenine pathway (KP) and one of its end products,
quinolinic acid (QUIN) play a role in the pathogenesis of several major neurological …

Within the last few years, knowledge about vitamins has increased dramatically. This new
edition of a bestseller presents comprehensive summaries that analyze the chemical …

Depression during pregnancy and the post-partum is common, with severe cases resulting
in suicidal behavior. Despite the urgent and unmet medical need, the biological …