Designing scaffolds for corneal regeneration

M Ahearne, J Fernández‐Pérez… - Advanced Functional …, 2020 - Wiley Online Library
Corneal blindness is one of the most common causes of vision loss worldwide, affecting
millions of people. To treat these patients, researchers have been examining different …

Corneal repair and regeneration: current concepts and future directions

M Mobaraki, R Abbasi, S Omidian Vandchali… - … in Bioengineering and …, 2019 - frontiersin.org
The cornea is a unique tissue and the most powerful focusing element of the eye, known as
a window to the eye. Infectious or non-infectious diseases might cause severe visual …

Effect of sterilization methods on electrospun poly (lactic acid)(PLA) fiber alignment for biomedical applications

TAM Valente, DM Silva, PS Gomes… - … applied materials & …, 2016 - ACS Publications
Medically approved sterility methods should be a major concern when developing a
polymeric scaffold, mainly when commercialization is envisaged. In the present work, poly …

Bioengineering approaches for corneal regenerative medicine

SS Mahdavi, MJ Abdekhodaie, S Mashayekhan… - Tissue engineering and …, 2020 - Springer
Background: Since the cornea is responsible for transmitting and focusing light into the eye,
injury or pathology affecting any layer of the cornea can cause a detrimental effect on visual …

Nanostructured scaffold as a determinant of stem cell fate

L Krishna, K Dhamodaran, C Jayadev… - Stem Cell Research & …, 2016 - Springer
The functionality of stem cells is tightly regulated by cues from the niche, comprising both
intrinsic and extrinsic cell signals. Besides chemical and growth factors, biophysical signals …

Aligned electrospun cellulose scaffolds coated with rhBMP-2 for both in vitro and in vivo bone tissue engineering

X Zhang, C Wang, M Liao, L Dai, Y Tang, H Zhang… - Carbohydrate …, 2019 - Elsevier
Physical properties of scaffolds such as nanofibers and aligned structures have been
reported to exert profound effects on the growth and differentiation of stem cells due to their …

Degradation and characterisation of electrospun polycaprolactone (PCL) and poly (lactic-co-glycolic acid)(PLGA) scaffolds for vascular tissue engineering

M Bazgir, W Zhang, X Zhang, J Elies, M Saeinasab… - Materials, 2021 - mdpi.com
The current study aimed to evaluate the characteristics and the effects of degradation on the
structural properties of Poly (lactic-co-glycolic acid)(PLGA)-and polycaprolactone (PCL) …

Electrospun scaffolds for corneal tissue engineering: A review

B Kong, S Mi - Materials, 2016 - mdpi.com
Corneal diseases constitute the second leading cause of vision loss and affect more than 10
million people globally. As there is a severe shortage of fresh donated corneas and an …

Biosynthetic PCL-graft-Collagen Bulk Material for Tissue Engineering Applications

P Gentile, K McColgan-Bannon, NC Gianone, F Sefat… - Materials, 2017 - mdpi.com
Biosynthetic materials have emerged as one of the most exciting and productive fields in
polymer chemistry due to their widespread adoption and potential applications in tissue …

Stem cell niche microenvironment

M Abdul-Al, GK Kyeremeh, M Saeinasab… - Bioengineering, 2021 - mdpi.com
The cornea comprises a pool of self-regenerating epithelial cells that are crucial to
preserving clarity and visibility. Limbal epithelial stem cells (LESCs), which live in a …