The biology and functional importance of MAIT cells
DI Godfrey, HF Koay, J McCluskey, NA Gherardin - Nature immunology, 2019 - nature.com
In recent years, a population of unconventional T cells called 'mucosal-associated invariant
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their …
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their …
[HTML][HTML] T-cell exhaustion in chronic infections: reversing the state of exhaustion and reinvigorating optimal protective immune responses
T-cell exhaustion is a phenomenon of dysfunction or physical elimination of antigen-specific
T cells reported in human immunodeficiency virus (HIV), hepatitis B virus (HBV), and …
T cells reported in human immunodeficiency virus (HIV), hepatitis B virus (HBV), and …
Intracellular pathogens: host immunity and microbial persistence strategies
A Thakur, H Mikkelsen… - Journal of immunology …, 2019 - Wiley Online Library
Infectious diseases caused by pathogens including viruses, bacteria, fungi, and parasites
are ranked as the second leading cause of death worldwide by the World Health …
are ranked as the second leading cause of death worldwide by the World Health …
[HTML][HTML] Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response
BP Keenan, L Fong, RK Kelley - Journal for immunotherapy of cancer, 2019 - Springer
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and
confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors …
confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors …
[HTML][HTML] Targeting Tim-3 in cancer with resistance to PD-1/PD-L1 blockade
T Tian, Z Li - Frontiers in oncology, 2021 - frontiersin.org
Programmed death receptor 1 (PD-1) or programmed death ligand 1 (PD-L1) blocking
therapy has completely changed the treatment pattern of malignant tumors. It has been …
therapy has completely changed the treatment pattern of malignant tumors. It has been …
Activated and exhausted MAIT cells foster disease progression and indicate poor outcome in hepatocellular carcinoma
M Duan, S Goswami, JY Shi, LJ Wu, XY Wang… - Clinical Cancer …, 2019 - AACR
Purpose: Innate immunity is an indispensable arm of tumor immune surveillance, and the
liver is an organ with a predominance of innate immunity, where mucosal-associated …
liver is an organ with a predominance of innate immunity, where mucosal-associated …
[HTML][HTML] Advances in targeting the innate and adaptive immune systems to cure chronic hepatitis B virus infection
Z Meng, Y Chen, M Lu - Frontiers in Immunology, 2020 - frontiersin.org
“Functional cure” is being pursued as the ultimate endpoint of antiviral treatment in chronic
hepatitis B (CHB), which is characterized by loss of HBsAg whether or not anti-HBs …
hepatitis B (CHB), which is characterized by loss of HBsAg whether or not anti-HBs …
[HTML][HTML] Single-cell transcriptional profiling reveals signatures of helper, effector, and regulatory MAIT cells during homeostasis and activation
Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that recognize
microbial vitamin B metabolites and have emerging roles in infectious disease …
microbial vitamin B metabolites and have emerging roles in infectious disease …
[HTML][HTML] MAIT cells in liver inflammation and fibrosis
H Mehta, MJ Lett, P Klenerman… - Seminars in …, 2022 - Springer
Mucosal-associated invariant T cells or MAIT cells are an abundant cell type in humans and
especially so in the liver. MAIT cells are a subset of T lymphocytes that sit at a bridge …
especially so in the liver. MAIT cells are a subset of T lymphocytes that sit at a bridge …
[HTML][HTML] Emerging features of MAIT cells and other unconventional T cell populations in human viral disease and vaccination.
CP Hackstein, P Klenerman - Seminars in Immunology, 2022 - Elsevier
MAIT cells are one representative of a group of related unconventional or pre-set T cells,
and are particularly abundant in humans. While these unconventional T cell types, which …
and are particularly abundant in humans. While these unconventional T cell types, which …