[HTML][HTML] Phosphorylated tau in Alzheimer's disease and other tauopathies
Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …
[HTML][HTML] Tau post-translational modifications: dynamic transformers of tau function, degradation, and aggregation
C Alquezar, S Arya, AW Kao - Frontiers in neurology, 2021 - frontiersin.org
Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …
protein function and contributing to neurodegeneration. The explosion of information on …
Structure-based classification of tauopathies
The ordered assembly of tau protein into filaments characterizes several neurodegenerative
diseases, which are called tauopathies. It was previously reported that, by cryo-electron …
diseases, which are called tauopathies. It was previously reported that, by cryo-electron …
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease. ApoE4 increases
brain amyloid-β pathology relative to other ApoE isoforms. However, whether APOE …
brain amyloid-β pathology relative to other ApoE isoforms. However, whether APOE …
[HTML][HTML] Roles of tau protein in health and disease
Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …
[HTML][HTML] Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
B Caballero, M Bourdenx, E Luengo, A Diaz… - Nature …, 2021 - nature.com
Disrupted homeostasis of the microtubule binding protein tau is a shared feature of a set of
neurodegenerative disorders known as tauopathies. Acetylation of soluble tau is an early …
neurodegenerative disorders known as tauopathies. Acetylation of soluble tau is an early …
Frontotemporal dementia
NT Olney, S Spina, BL Miller - Neurologic clinics, 2017 - neurologic.theclinics.com
Frontotemporal dementia (FTD) has undergone numerous changes in nomenclature and
categorization schemes since it was first described by Pick in 1892. Presently, FTD …
categorization schemes since it was first described by Pick in 1892. Presently, FTD …
Primary age-related tauopathy (PART): a common pathology associated with human aging
JF Crary, JQ Trojanowski, JA Schneider… - Acta …, 2014 - Springer
We recommend a new term,“primary age-related tauopathy”(PART), to describe a pathology
that is commonly observed in the brains of aged individuals. Many autopsy studies have …
that is commonly observed in the brains of aged individuals. Many autopsy studies have …
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
Tauopathies, including frontotemporal dementia (FTD) and Alzheimer's disease (AD), are
neurodegenerative diseases in which tau fibrils accumulate. Recent evidence supports …
neurodegenerative diseases in which tau fibrils accumulate. Recent evidence supports …
Invited review: neuropathology of tauopathies: principles and practice
GG Kovacs - Neuropathology and applied neurobiology, 2015 - Wiley Online Library
Tauopathies are clinically, morphologically and biochemically heterogeneous
neurodegenerative diseases characterized by the deposition of abnormal tau protein in the …
neurodegenerative diseases characterized by the deposition of abnormal tau protein in the …