The role of cyclooxygenases in inflammation, cancer, and development
CS Williams, M Mann, RN DuBois - Oncogene, 1999 - nature.com
The cyclooxygenase (COX) enzymes catalyze a key step in the conversion of arachidonate
to PGH 2, the immediate substrate for a series of cell specific prostaglandin and …
to PGH 2, the immediate substrate for a series of cell specific prostaglandin and …
Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2
RA Gupta, RN DuBois - Nature Reviews Cancer, 2001 - nature.com
Population-based studies have established that long-term intake of non-steroidal anti-
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …
Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands
The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …
Nanoemulsion based gel for transdermal delivery of meloxicam: physico-chemical, mechanistic investigation
AIMS: The aim of the present investigation was to develop a nanoemulsion (NE) gel
formulation for the transdermal delivery of meloxicam (MLX) in order to ensure maximum …
formulation for the transdermal delivery of meloxicam (MLX) in order to ensure maximum …
Prostacyclin-mediated activation of peroxisome proliferator-activated receptor δ in colorectal cancer
RA Gupta, J Tan, WF Krause… - Proceedings of the …, 2000 - National Acad Sciences
There is evidence from both genetic and pharmacologic studies to suggest that the
cyclooxygenase-2 (COX-2) enzyme plays a causal role in the development of colorectal …
cyclooxygenase-2 (COX-2) enzyme plays a causal role in the development of colorectal …
Metal complexes of NSAIDs as potent anti-tumor chemotherapeutics: Mechanistic insights into cytotoxic activity via multiple pathways primarily by inhibition of COX–1 …
Non–steroidal anti-inflammatory drugs (NSAIDs) have gained considerable attention due to
their well–established medicinal properties such as anti-inflammatory, anti-bacterial, anti …
their well–established medicinal properties such as anti-inflammatory, anti-bacterial, anti …
Cyclooxygenase-2: a target for the prevention and treatment of breast cancer.
LR Howe, K Subbaramaiah, AM Brown… - Endocrine-related …, 2001 - erc.bioscientifica.com
Cyclooxygenase-2 (COX-2), an inducible prostaglandin synthase, is normally expressed in
parts of the kidney and brain. Aberrant COX-2 expression was first reported in colorectal …
parts of the kidney and brain. Aberrant COX-2 expression was first reported in colorectal …
Celecoxib Prevents Tumor Growth in Vivo without Toxicity to Normal Gut: Lack of Correlation between in Vitro and in Vivo Models
CS Williams, AJM Watson, H Sheng, R Helou, J Shao… - Cancer research, 2000 - AACR
Nonsteroidal anti-inflammatory drugs have potential for use in the prevention and/or
treatment of colorectal cancer. We have studied the cytotoxic effect of a specific COX-2 …
treatment of colorectal cancer. We have studied the cytotoxic effect of a specific COX-2 …
The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action
ML Smith, G Hawcroft, MA Hull - European journal of cancer, 2000 - Elsevier
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit proliferation and induce apoptosis in
human colorectal cancer cells in vitro. It remains unclear whether individual NSAIDs act by …
human colorectal cancer cells in vitro. It remains unclear whether individual NSAIDs act by …
The potential contributions of chronic inflammation to lung carcinogenesis
S Ballaz, JL Mulshine - Clinical lung cancer, 2003 - Elsevier
A number of lines of evidence suggests that chronic inflammation contributes to the process
of carcinogenesis. In this article, this theme is explored with particular emphasis on the …
of carcinogenesis. In this article, this theme is explored with particular emphasis on the …