The mammalian lung´ s structural design is optimized to serve its main function: gas
exchange. It takes place in the alveolar region (parenchyma) where air and blood are …

We describe a microfabricated airway system integrated with computerized air–liquid two-
phase microfluidics that enables on-chip engineering of human airway epithelia and precise …

Mechanotransduction has been a topic of considerable interest since early studies
demonstrated a link between mechanical force and biological response. Until recently …

Mechanical ventilation applies physical stresses to the tissues of the lung and thus may give
rise to ventilator-induced lung injury (VILI), particular in patients with acute respiratory …

We provide a selective review of recent progress in the analysis of several physiological and
physiologically inspired fluid-structure interaction problems, our aim being to explain the …

Computational modelling of the lungs is an active field of study that integrates computational
advances with lung biophysics, biomechanics, physiology and medical imaging to promote …

Protective ventilation strategies for the injured lung currently revolve around the use of low
Vt, ostensibly to avoid volutrauma, together with positive end-expiratory pressure to increase …

By airway surface liquid, we mean a thin fluid continuum consisting of the airway lining layer
and the alveolar lining layer, which not only serves as a protective barrier against foreign …

Epithelial cells of the lung are located at the interface between the environment and the
organism and serve many important functions including barrier protection, fluid balance …

Idiopathic pulmonary fibrosis (IPF) and bleomycin-induced pulmonary fibrosis are
associated with surfactant system dysfunction, alveolar collapse (derecruitment), and …