Early-onset preeclampsia has been linked to poor placentation and fetal growth restriction,
whereas late-onset preeclampsia was suggested to result from maternal factors. We have …

Abnormal placentation is considered as an underlying cause of various pregnancy
complications such as miscarriage, preeclampsia and intrauterine growth restriction, the …

Physiological transformation with remodeling of the uteroplacental spiral arteries is key to a
successful placentation and normal placental function. It is an intricate process that involves …

The blastocyst (the early mammalian embryo) forms all embryonic and extra-embryonic
tissues, including the placenta. It consists of a spherical thin-walled layer, known as the …

Interventions to prevent pregnancy complications have been largely unsuccessful. We
suggest this is because the foundation for a healthy pregnancy is laid prior to the …

Dysregulated extravillous trophoblast invasion and proliferation are known to increase the
risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains …

Oxygen levels in the placental microenvironment throughout gestation are not constant, with
severe hypoxic conditions present during the first trimester. This hypoxic phase overlaps …

Successful establishment of pregnancy requires adhesion of an embryo to the endometrium
and subsequent invasion into the maternal tissue. Abnormalities in this critical process of …

Preeclampsia is a serious complication of pregnancy where it affects 5–8% of all
pregnancies. It increases the morbidity and mortality of both the fetus and pregnant woman …

The placenta sits at the interface between the maternal and fetal vascular beds where it
mediates nutrient and waste exchange to enable in utero existence. Placental cells …