In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …

Highlights•Kinetoplastids do not control transcription of individual protein-coding
genes.•mRNAs are made from polycistronic precursors by trans splicing and …

Developmental steps in the trypanosome life-cycle involve transition between replicative
and non-replicative forms specialised for survival in, and transmission between, mammalian …

Control of gene expression at the post‐transcriptional level is essential in all organisms, and
RNA‐binding proteins play critical roles from mRNA synthesis to decay. To fully understand …

Background Trypanosoma brucei subspecies infect humans and animals in sub-Saharan
Africa. This early diverging eukaryote shows many novel features in basic biological …

The genome organization of trypanosomes, leishmanias, and related kinetoplastid
organisms is highly unusual: Each RNA polymerase II promoter precedes multiple open …

In trypanosomatids, gene expression is regulated mainly by post-transcriptional
mechanisms, which affect mRNA processing, translation and degradation. Currently, our …

In nearly all eukaryotes, cellular differentiation is governed by changes in transcription, and
stabilized by chromatin and DNA modification. Gene expression control in the pathogen …

One of the key questions in understanding the biology of an organism is how to correlate
cellular fate and function with gene expression patterns. This is particularly relevant for …

The kinetoplastid parasite, Trypanosoma brucei, undergoes a complex life cycle entailing
slender and stumpy bloodstream forms in mammals and procyclic and metacyclic forms …