Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …

The prevailing notion that reduced cofactors NADH and FADH 2 transfer electrons from the
tricarboxylic acid cycle to the mitochondrial electron transfer system creates ambiguities …

Respiratory complex I is a~ 1-MDa proton pump in mitochondria. Its structure has been
revealed in great detail, but the structural basis of its assembly, in humans involving at least …

Human mitochondrial ATP synthase is a molecular machine with a rotary action bound in the
inner organellar membranes. Turning of the rotor, driven by a proton motive force, provides …

The dual function protein ACAD9 catalyzes α, β-dehydrogenation of fatty acyl-CoA thioesters
in fatty acid β-oxidation and is an essential chaperone for mitochondrial respiratory complex …

Alzheimer's disease (AD) is the most common neurodegenerative disorder and the main
cause of dementia which is characterized by a progressive cognitive decline that severely …

Alzheimer's disease (AD) is a progressive neurodegenerative disease with no cure where
the underlying causes remain elusive. Mitochondrial dysfunction has become a prime …

The flavin mononucleotide (FMN) cofactor of respiratory complex I occupies a key position in
the electron transport chain. Here, the electrons coming from NADH start the sequence of …

A decade ago I postulated that ROS formation in mitochondria was influenced by different
FADH2/NADH (F/N) ratios of catabolic substrates. Thus, fatty acid oxidation (FAO) would …

Mitochondrial dysfunction is a key factor in exacerbating pressure overload‐induced cardiac
hypertrophy and is linked to increased morbidity and mortality. ECSIT, a crucial adaptor for …