[HTML][HTML] The energy balance model of obesity: beyond calories in, calories out

KD Hall, IS Farooqi, JM Friedman, S Klein… - The American journal of …, 2022 - Elsevier
ABSTRACT A recent Perspective article described the “carbohydrate-insulin model (CIM)” of
obesity, asserting that it “better reflects knowledge on the biology of weight control” as …

[HTML][HTML] The carbohydrate-insulin model: a physiological perspective on the obesity pandemic

DS Ludwig, LJ Aronne, A Astrup, R de Cabo… - The American journal of …, 2021 - Elsevier
According to a commonly held view, the obesity pandemic is caused by overconsumption of
modern, highly palatable, energy-dense processed foods, exacerbated by a sedentary …

Ketogenic diets, physical activity and body composition: a review

D Ashtary-Larky, R Bagheri, H Bavi, JS Baker… - British Journal of …, 2022 - cambridge.org
Obesity remains a serious relevant public health concern throughout the world despite
related countermeasures being well understood (ie mainly physical activity and an adjusted …

Carbohydrates, insulin, and obesity

JR Speakman, KD Hall - Science, 2021 - science.org
The primary cause of common human obesity remains uncertain. There are several
plausible explanations, including the popular “carbohydrate-insulin” model (CIM), which …

[HTML][HTML] Intermittent fasting for obesity and related disorders: unveiling myths, facts, and presumptions

B Halpern, TB Mendes - Archives of Endocrinology and Metabolism, 2021 - SciELO Brasil
Intermittent fasting (IF) is an increasingly popular method of weight loss, as an alternative to
daily caloric restriction (DCR). Several forms of IF exist, such as alternate-day fasting or time …

[HTML][HTML] Disentangling the effects of obesity and high-fat diet on glucose homeostasis using a photoperiod induced obesity model implicates ectopic fat deposition as a …

DB Yang, L Gao, XY Liu, YC Xu, C Hambly… - Molecular …, 2023 - Elsevier
Objective Obesity in laboratory rodents is generally induced by feeding them a high fat diet
(HFD). This model does not permit separation of the impact of the HFD from the resultant …

[HTML][HTML] Protein quality and quantity influence the effect of dietary fat on weight gain and tissue partitioning via host-microbiota changes

O Nychyk, W Barton, AM Rudolf, S Boscaini, A Walsh… - Cell Reports, 2021 - cell.com
We investigated how protein quantity (10%–30%) and quality (casein and whey) interact
with dietary fat (20%–55%) to affect metabolic health in adult mice. Although dietary fat was …

[HTML][HTML] Increased variation in body weight and food intake is related to increased dietary fat but not increased carbohydrate or protein in mice

Y Wu, S Hu, D Yang, L Li, B Li, L Wang, M Li… - Frontiers in …, 2022 - frontiersin.org
A variety of inbred mouse strains have been used for research in metabolic disorders.
Despite being inbred, they display large inter-individual variability for many traits like food …

[HTML][HTML] Testing the carbohydrate-insulin model in mice: the importance of distinguishing primary hyperinsulinemia from insulin resistance and metabolic dysfunction

DS Ludwig, CB Ebbeling, BT Bikman… - Molecular …, 2020 - ncbi.nlm.nih.gov
DSL received royalties for books on obesity and nutrition that recommend a carbohydrate-
modified diet and grants from the NIH and philanthropic organizations unaffiliated with the …

Obesity in C57BL/6J mice fed diets differing in carbohydrate and fat but not energy content

MG Tordoff, HT Ellis - Physiology & behavior, 2022 - Elsevier
To investigate the contributions of carbohydrate and fat to obesity we measured the body
weight, body composition and food intake of adult C57BL/6J mice fed ad libitum with various …