Corticosteroids in ophthalmology: Drug delivery innovations, pharmacology, clinical applications, and future perspectives

SA Gaballa, UB Kompella, O Elgarhy… - Drug Delivery and …, 2021 - Springer
Corticosteroids remain the mainstay of the treatment for various ocular conditions affecting
the ocular surface, anterior and posterior segments of the eye due to their anti-inflammatory …

COVID‐19 drug repurposing: a review of computational screening methods, clinical trials, and protein interaction assays

X Wang, Y Guan - Medicinal research reviews, 2021 - Wiley Online Library
The situation of coronavirus disease 2019 (COVID‐19) pandemic is rapidly evolving, and
medical researchers around the globe are dedicated to finding cures for the disease. Drug …

Topical sustained drug delivery to the retina with a drug-eluting contact lens

AE Ross, LC Bengani, R Tulsan, DE Maidana… - Biomaterials, 2019 - Elsevier
Intravitreal injections and implants are used to deliver drugs to the retina because
therapeutic levels of these medications cannot be provided by topical administration (ie eye …

Implantable drug delivery systems and foreign body reaction: Traversing the current clinical landscape

A Fayzullin, A Bakulina, K Mikaelyan, A Shekhter… - Bioengineering, 2021 - mdpi.com
Precise delivery of therapeutics to the target structures is essential for treatment efficiency
and safety. Drug administration via conventional routes requires overcoming multiple …

Dexamethasone inserts in noninfectious uveitis: a single-center experience

D Pohlmann, GA Vom Brocke, S Winterhalter, T Steurer… - Ophthalmology, 2018 - Elsevier
Purpose To report the effectiveness of repeated intravitreal dexamethasone (DEX) inserts in
noninfectious uveitis patients. Design Prospective, single-center, interventional clinical trial …

Recombinant thrombomodulin domain 1 rescues pathological angiogenesis by inhibition of HIF-1α-VEGF pathway

YH Huang, CH Kuo, IC Peng, YS Chang… - Cellular and Molecular …, 2021 - Springer
Pathological angiogenesis (PA) contributes to various ocular diseases, including age-
related macular degeneration, diabetic retinopathy, and retinopathy of prematurity, which …

Ophthalmic drops with nanoparticles derived from a natural product for treating age-related macular degeneration

G Xin, M Zhang, Z Zhong, L Tang, Y Feng… - … Applied Materials & …, 2020 - ACS Publications
There is a continuing, urgent need for an ophthalmic (eye) drop for the clinical therapy of
age-related macular degeneration (AMD), a leading cause of blindness. Here, we report the …

Research models of sulfur mustard-and nitrogen mustard-induced ocular injuries and potential therapeutics

N Mishra, R Agarwal - Experimental eye research, 2022 - Elsevier
Sulfur mustard (SM) is a notorious, bifunctional alkylating vesicant that was first used in
warfare during World War I in 1917 and since then has been deployed in numerous …

Bioadhesive glycosylated nanoformulations for extended trans-corneal drug delivery to suppress corneal neovascularization

Y Zhang, Y Yu, G Li, X Zhang, Z Wu… - Journal of Materials …, 2021 - pubs.rsc.org
Eye-drop formulations as conventional regimens to tackle ocular diseases are far from
efficient due to the rapid clearance by eye tears and the blockage of the corneal epithelium …

Comparison between Ozurdex and intravitreal anti-vascular endothelial growth factor treatment for retinal vein occlusion–related macular edema: A systematic review …

Q Hu, H Li, W Xu, Y Du, C Ma, J He - Indian journal of …, 2019 - journals.lww.com
This systematic review aimed to evaluate the effectiveness and safety of intravitreal
dexamethasone (DEX) implant and intravitreal anti-vascular endothelial growth factor …