The liver microcirculatory milieu, mainly composed of liver sinusoidal endothelial cells
(LSECs), hepatic stellate cells (HSCs) and hepatic macrophages, has an essential role in …

Portal hypertension is a severe and frequent complication of chronic liver disease. Its
consequences, bleeding from gastroesophageal varices and portal hypertensive …

Variceal bleeding is the last step in a chain of events initiated by an increase in portal
pressure, followed by the development and progressive dilation of varices until these finally …

Portal hypertension is the main cause of complications in patients with chronic liver disease.
Over the past 25years, progress in the understanding of the pathophysiology of portal …

Portal hypertension is a major cause of morbidity and mortality in liver cirrhosis. This article
provides a background on the most important aspects of the evaluation of portal …

Abstract In a long‐term (10‐year) study of radiofrequency ablation (RFA) of hepatocellular
carcinoma (HCC) as bridging therapy in patients listed for orthotopic liver transplantation …

In cirrhosis, increased intrahepatic vascular resistance (IHVR) is the primary factor for portal
hypertension (PH) development. Hepatic stellate cells (HSCs) play a major role increasing …

In cirrhotic livers, decreased nitric oxide (NO) bioavailability is a major factor increasing
intrahepatic vascular tone. In several vascular disorders, an increase in superoxide (O2−) …

BACKGROUND & AIMS: Resveratrol, a polyphenol found in a variety of fruits, exerts a wide
range of beneficial effects on the endothelium, regulates multiple vasoactive substances and …

The initial factor leading to portal hypertension is an increase in hepatic resistance. Later, an
increase in portal blood flow contributes to maintain and exacerbate portal hypertension …