The majority of rare diseases affect children, most of whom have an underlying genetic
cause for their condition. However, making a molecular diagnosis with current technologies …

Introduction Invasive meningococcal disease (IMD) is uncommon but still causes
considerable public health burden due to its high mortality and morbidity. This review aims …

Despite considerable advances in the understanding of the pathogenesis of meningococcal
disease, this infection remains a major cause of morbidity and mortality globally. The role of …

Bloodstream infections (BSIs) and sepsis rank among the top reasons for human mortality
for hospitalized patients. The full breadth of sepsis syndromes are particularly dangerous to …

Neisseria meningitidis is a human-specific bacterium that varies in invasive potential. All
meningococci are carried in the nasopharynx, and most genotypes are very infrequently …

Severe infection and the patient response constitute sepsis. Here, we review the meta-
genome (patient genetics, pathogen communities and host response) and its impact upon …

Some members of the physiological human microbiome occasionally cause life-threatening
disease even in immunocompetent individuals. A prime example of such a commensal …

Whole genome sequencing of bacteria is important to enable strain classification. Using
entire genomes as an input to machine learning (ML) models would allow rapid …

Bacteria cause disease by two general mechanisms: the action of their toxins on host cells
and induction of a pro-inflammatory response that can lead to a deleterious …

Neisseria meningitidis (Nm) is frequently found in the upper respiratory tract of the human
population. Despite its prevalence as a commensal organism, Nm can occasionally invade …