Today's biologics manufacturing practices incur high costs to the drug makers, which can
contribute to high prices for patients. Timely investment in the development and …

This review is the tenth update of the original article published in 1999 on the application of
matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of …

Replacement of serum and increasing use of chemically defined media demands
optimisation of trace metal components for biomanufacturing applications. Trace metal …

Explosive pollutants remaining in global soils are serious threats to human health and
ecological safety. Soils contaminated by trinitrotoluene (TNT) and cyclotrimethylene …

It is well established that the metal content in Chinese hamster ovary (CHO) cell culture
media (CCM) greatly affects process productivity and critical quality attributes (CQAs) …

Over the past decade, global interest in the development of therapeutic monoclonal
antibodies (mAbs) has risen rapidly. As therapeutic agents, antibodies have shown marked …

In recombinant protein production, cell culture media development and optimization is
typically seen as a useful strategy to increase titer and cell density, reduce by-products, as …

Background Determining the cytotoxicity of test substances is essential for the safety
assessment of chemicals. To quantify the cytotoxicity, dose–response curves are determined …

Retrospective analysis of historic data for cell culture processes is a powerful tool to develop
further process understanding. In particular, deploying retrospective analyses can identify …

Mammalian cell cultures have been used extensively for production of recombinant protein
therapeutics such as monoclonal antibodies, fusion proteins and enzymes for decades …