The great immune escape: understanding the divergent immune response in breast cancer subtypes
Breast cancer, the most common type of cancer affecting women, encompasses a collection
of histologic (mainly ductal and lobular) and molecular subtypes exhibiting diverse clinical …
of histologic (mainly ductal and lobular) and molecular subtypes exhibiting diverse clinical …
The pregnancy-associated plasma protein-A (PAPP-A) story
CA Conover, C Oxvig - Endocrine reviews, 2023 - academic.oup.com
Pregnancy-associated plasma protein-A (PAPP-A) was first identified in the early 1970s as a
placental protein of unknown function, present at high concentrations in the circulation of …
placental protein of unknown function, present at high concentrations in the circulation of …
CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer
JM Houthuijzen, R De Bruijn, E Van Der Burg… - Nature …, 2023 - nature.com
Cancer-associated fibroblasts (CAFs) are abundantly present in the microenvironment of
virtually all tumors and strongly impact tumor progression. Despite increasing insight into …
virtually all tumors and strongly impact tumor progression. Despite increasing insight into …
Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism
The metzincin metalloproteinase PAPP-A plays a key role in the regulation of insulin-like
growth factor (IGF) signaling by specific cleavage of inhibitory IGF binding proteins (IGFBPs) …
growth factor (IGF) signaling by specific cleavage of inhibitory IGF binding proteins (IGFBPs) …
The insulin-like growth factor signaling pathway in breast cancer: an elusive therapeutic target
JS Lee, CE Tocheny, LM Shaw - Life, 2022 - mdpi.com
In this review, we provide an overview of the role of the insulin-like growth factor (IGF)
signaling pathway in breast cancer and discuss its potential as a therapeutic target. The IGF …
signaling pathway in breast cancer and discuss its potential as a therapeutic target. The IGF …
Lobular carcinoma of the breast: A comprehensive review with translational insights
Simple Summary Invasive lobular carcinoma (ILC), the second most common type of breast
cancer, is a distinct entity. Despite their unique biology and clinical course, lobular …
cancer, is a distinct entity. Despite their unique biology and clinical course, lobular …
Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling
Autophagy is a conserved cellular degradation process. While autophagy-related proteins
were shown to influence the signaling and trafficking of some receptor tyrosine kinases, the …
were shown to influence the signaling and trafficking of some receptor tyrosine kinases, the …
Mapping cancer biology in space: applications and perspectives on spatial omics for oncology
Technologies to decipher cellular biology, such as bulk sequencing technologies and single-
cell sequencing technologies, have greatly assisted novel findings in tumor biology. Recent …
cell sequencing technologies, have greatly assisted novel findings in tumor biology. Recent …
Exploration of cancer associated fibroblasts phenotypes in the tumor microenvironment of classical and pleomorphic Invasive Lobular Carcinoma
H Batra, Q Ding, R Pandurengan, H Ibarguen… - Frontiers in …, 2023 - frontiersin.org
As the second most common subtype of breast carcinoma, Invasive Lobular Carcinoma
(ILC) microenvironment features have not been thoroughly explored. ILC has different …
(ILC) microenvironment features have not been thoroughly explored. ILC has different …
Single‐cell RNA‐sequencing of retrieved human oocytes and eggs in clinical practice and for human ovarian cell atlasing
JH Machlin, A Shikanov - Molecular reproduction and …, 2022 - Wiley Online Library
With the advancement of single‐cell separation techniques and high‐throughput
sequencing platforms, single‐cell RNA‐sequencing (scRNA‐seq) has emerged as a vital …
sequencing platforms, single‐cell RNA‐sequencing (scRNA‐seq) has emerged as a vital …