Breast cancer, the most common type of cancer affecting women, encompasses a collection
of histologic (mainly ductal and lobular) and molecular subtypes exhibiting diverse clinical …

Pregnancy-associated plasma protein-A (PAPP-A) was first identified in the early 1970s as a
placental protein of unknown function, present at high concentrations in the circulation of …

Cancer-associated fibroblasts (CAFs) are abundantly present in the microenvironment of
virtually all tumors and strongly impact tumor progression. Despite increasing insight into …

The metzincin metalloproteinase PAPP-A plays a key role in the regulation of insulin-like
growth factor (IGF) signaling by specific cleavage of inhibitory IGF binding proteins (IGFBPs) …

In this review, we provide an overview of the role of the insulin-like growth factor (IGF)
signaling pathway in breast cancer and discuss its potential as a therapeutic target. The IGF …

Simple Summary Invasive lobular carcinoma (ILC), the second most common type of breast
cancer, is a distinct entity. Despite their unique biology and clinical course, lobular …

Autophagy is a conserved cellular degradation process. While autophagy-related proteins
were shown to influence the signaling and trafficking of some receptor tyrosine kinases, the …

Technologies to decipher cellular biology, such as bulk sequencing technologies and single-
cell sequencing technologies, have greatly assisted novel findings in tumor biology. Recent …

As the second most common subtype of breast carcinoma, Invasive Lobular Carcinoma
(ILC) microenvironment features have not been thoroughly explored. ILC has different …

With the advancement of single‐cell separation techniques and high‐throughput
sequencing platforms, single‐cell RNA‐sequencing (scRNA‐seq) has emerged as a vital …