Constructs having a SIRP-α domain or variant thereof

J Pons, L Deming, C Goodman, BJ Sim… - US Patent …, 2019 - Google Patents
2016-08-31 Assigned to Alexo Therapeutics Inc. reassignment Alexo Therapeutics Inc.
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …

Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS

M Eisenbach-Schwartz, K Baruch… - US Patent …, 2019 - Google Patents
The present specification discloses a pharmaceutical composition comprising an active
agent that causes reduction of the level of systemic immunosuppression in an individual for …

Constructs having a SIRP-alpha domain or variant thereof

J Pons, BJ Sim, SE Kauder, H Wan… - US Patent 10,696,730, 2020 - Google Patents
The present disclosure features signal-regulatory protein α (SIRPα) polypeptides and
constructs that are useful, eg, to target a cell (eg, a cancer cell or a cell of the immune …

Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS

M Eisenbach-Schwartz, K Baruch… - US Patent …, 2020 - Google Patents
2017-11-29 Assigned to YEDA RESEARCH AND DEVELOPMENT CO., LTD. reassignment
YEDA RESEARCH AND DEVELOPMENT CO., LTD. ASSIGNMENT OF ASSIGNORS …

Reducing systemic regulatory T cell levels or activity for treatment of Alzheimer's disease

M Eisenbach-Schwartz, K Baruch… - US Patent …, 2018 - Google Patents
A pharmaceutical composition comprising an active agent that causes reduction of the level
of systemic immunosuppression in an individual for use in treating a disease, disorder …

Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS

M Eisenbach-Schwartz, K Baruch… - US Patent …, 2018 - Google Patents
A pharmaceutical composition comprising an active agent that causes reduction of the level
of systemic immunosuppression in an individual for use in treating a disease, disorder …

Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease

M Eisenbach-Schwartz, K Baruch… - US Patent …, 2018 - Google Patents
A pharmaceutical composition comprising an active agent that causes reduction of the level
of systemic immunosuppression in an individual for use in treating a disease, disorder …

Reducing systemic regulatory T cell levels or activity for treatment of Alzheimer's disease

M Eisenbach-Schwartz, K Baruch… - US Patent …, 2018 - Google Patents
A pharmaceutical composition comprising an active agent that causes reduction of the level
of systemic immunosuppression in an individual for use in treating a disease, disorder …

Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease

M Eisenbach-Schwartz, K Baruch… - US Patent …, 2018 - Google Patents
A pharmaceutical composition comprising an active agent that causes reduction of the level
of systemic immunosuppression in an individual for use in treating a disease, disorder …

Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the CNS

M Eisenbach-Schwartz, K Baruch… - US Patent …, 2022 - Google Patents
The present specification discloses a pharmaceutical composition comprising an active
agent that causes reduction of the level of systemic immunosuppression in an individual for …