[HTML][HTML] Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation
Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
Pharmacogenomics of CYP2C9: Functional and Clinical Considerations†
CYP2C9 is the most abundant CYP2C subfamily enzyme in human liver and the most
important contributor from this subfamily to drug metabolism. Polymorphisms resulting in …
important contributor from this subfamily to drug metabolism. Polymorphisms resulting in …
Sex differences and the endocannabinoid system in pain
HL Blanton, RC Barnes, MC McHann, JA Bilbrey… - Pharmacology …, 2021 - Elsevier
Cannabis use has been increasing in recent years, particularly among women, and one of
the most common uses of cannabis for medical purposes is pain relief. Pain conditions and …
the most common uses of cannabis for medical purposes is pain relief. Pain conditions and …
Human cytochrome P450 enzymes
FP Guengerich - Cytochrome P450: structure, mechanism, and …, 2015 - Springer
Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
PharmVar GeneFocus: CYP2C9
K Sangkuhl, K Claudio‐Campos… - Clinical …, 2021 - Wiley Online Library
The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele
nomenclature for the polymorphic human CYP2C9 gene. Genetic variation within the …
nomenclature for the polymorphic human CYP2C9 gene. Genetic variation within the …
[PDF][PDF] OECD guideline for the testing of chemicals
PBT Guideline - The Hershberger, 2001 - ntp.niehs.nih.gov
1. This Performance-Based Test Guideline (PBTG) describes the methodology of Stably
Transfected Transactivation In Vitro Assays to detect Estrogen Receptor Agonists (ER TA …
Transfected Transactivation In Vitro Assays to detect Estrogen Receptor Agonists (ER TA …
Menstrual exacerbation of schizophrenia symptoms
MV Seeman - Acta psychiatrica scandinavica, 2012 - Wiley Online Library
Seeman MV. Menstrual exacerbation of schizophrenia symptoms. Objective: To better
understand premenstrual exacerbations of schizophrenia in women and weigh treatment …
understand premenstrual exacerbations of schizophrenia in women and weigh treatment …
[HTML][HTML] Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study
C Bernasconi, O Pelkonen, TB Andersson, J Strickland… - Toxicology in Vitro, 2019 - Elsevier
CYP enzyme induction is a sensitive biomarker for phenotypic metabolic competence of in
vitro test systems; it is a key event associated with thyroid disruption, and a biomarker for …
vitro test systems; it is a key event associated with thyroid disruption, and a biomarker for …
Interethnic differences in the relevance of CYP2C9 genotype and environmental factors for diclofenac metabolism in Hispanics from Cuba and Spain
The aims of this study were to evaluate the diclofenac metabolism in Hispanics from Cuba
and Spain and its relation to ethnicity, CYP2C9 genotypes and environmental factors …
and Spain and its relation to ethnicity, CYP2C9 genotypes and environmental factors …
Effect of Gender and CYP2C9 and CYP2C8 Polymorphisms on the Pharmacokinetics of Ibuprofen Enantiomers
D Ochoa, R Prieto-Perez, M Roman, M Talegon… - …, 2015 - Taylor & Francis
Aim: To evaluate the effect of polymorphisms in CYP2C9 and CYP2C8 and gender on the
pharmacokinetics of the enantiomeric forms of ibuprofen. Materials & methods: 122 healthy …
pharmacokinetics of the enantiomeric forms of ibuprofen. Materials & methods: 122 healthy …