According to the traditional understanding of cerebrospinal fluid (CSF) physiology, the
majority of CSF is produced by the choroid plexus, circulates through the ventricles, the …

Aquaporin-4 (AQP4) is the main water channel protein expressed in the central nervous
system (CNS). AQP4 is densely expressed in astrocyte end-feet, and is an important factor in …

The glymphatic system, that is aquaporin 4 (AQP4) facilitated exchange of CSF with
interstitial fluid (ISF), may provide a clearance pathway for protein species such as amyloid …

The discovery of the water specific channel, aquaporin, and abundant expression of its
isoform, aquaporin-4 (AQP-4), on astrocyte endfeet brought about significant advancements …

High-altitude cerebral edema (HACE) and acute mountain sickness (AMS) are
neuropathologies associated with rapid exposure to hypoxia. However, speculation remains …

Initially thought to be useful only to reach tissues in the immediate vicinity of the CSF
circulatory system, CSF circulation is now increasingly viewed as a viable pathway to deliver …

The classic hypothesis presents the cerebrospinal fluid (CSF) as the “third circulation,” which
flows from the brain ventricles through the entire CSF system to the cortical subarachnoid …

The blood-brain barrier (BBB) regulates the transfer of solutes and essential nutrients into
the brain. Growing evidence supports BBB dysfunction in a range of acute and chronic brain …

Cerebral stroke, which is one of the most frequent causes of mortality and leading cause of
disability in developed countries, often leads to devastating and irreversible brain damage …

Aims Neurovascular-glymphatic dysfunction plays an important role in Alzheimer's disease
and has been analysed mainly in relation to amyloid-beta (Aβ) pathology. Here, we aim to …