Hepatitis B virus research in South Africa

MB Maepa, A Ely, A Kramvis, K Bloom, K Naidoo… - Viruses, 2022 - mdpi.com
Despite being vaccine-preventable, hepatitis B virus (HBV) infection remains the seventh
leading cause of mortality in the world. In South Africa (SA), over 1.9 million people are …

[HTML][HTML] Epidemiology and aetiology of hepatocellular carcinoma in Sub-Saharan Africa

D Mak, A Kramvis - Hepatoma Research, 2021 - oaepublish.com
With the highest annual fatality ratio (mortality-to-incidence ratio), reported for a human
cancer, hepatocellular carcinoma (HCC) ranks as the third leading cause of cancer-related …

The global hepatitis B virus genotype distribution approximated from available genotyping data

S Velkov, JJ Ott, U Protzer, T Michler - Genes, 2018 - mdpi.com
Hepatitis B virus (HBV) is divided into nine genotypes, A to I. Currently, it remains unclear
how the individual genotypes contribute to the estimated 250 million chronic HBV infections …

[HTML][HTML] Prevalence, awareness and risk factors associated with Hepatitis B infection among pregnant women attending the antenatal clinic at Mbagathi District …

JAM Ngaira, J Kimotho, I Mirigi, S Osman… - The Pan African …, 2016 - ncbi.nlm.nih.gov
Methods This was a cross-sectional study involving 287 pregnant women enrolled for three
months (September to December 2014) from Nairobi and neighbouring counties. A …

Molecular characteristics and clinical relevance of African genotypes and subgenotypes of hepatitis B virus

A Kramvis - SAMJ: South African Medical Journal, 2018 - scielo.org.za
Hepatitis B virus (HBV), a DNA virus, replicates via an RNA intermediate, through reverse
transcription catalysed by the viral polymerase that lacks proof reading ability. Thus …

Screening and diagnosis of HBV in low-income and middle-income countries

JP Allain, O Opare-Sem - Nature reviews Gastroenterology & …, 2016 - nature.com
HBV testing and diagnosis of HBV-related liver disease in low-income and middle-income
countries differs substantially from that in developed countries in terms of access to …

[HTML][HTML] Review on hepatitis B virus precore/core promoter mutations and their correlation with genotypes and liver disease severity

R Kumar - World Journal of Hepatology, 2022 - ncbi.nlm.nih.gov
Of 350 million people worldwide are chronically infected with hepatitis B virus (HBV) and are
at risk of developing cirrhosis and hepatocellular carcinoma (HCC) later in life. HBV is the …

Mapping hepatitis B virus genotypes on the African continent from 1997 to 2021: A systematic review with meta-analysis

HM Kafeero, D Ndagire, P Ocama, CD Kato… - Scientific Reports, 2023 - nature.com
Hepatitis B virus (HBV) has ten genotypes (A–J) and over 40 sub-genotypes based on the
divergence of≥ 8% and 4 to< 8% in the complete genome respectively. These genotypes …

The burden of Hepatitis B virus infection in Kenya: A systematic review and meta-analysis

GN Makokha, P Zhang, CN Hayes, E Songok… - Frontiers in public …, 2023 - frontiersin.org
Background Chronic Hepatitis B virus (HBV) infection causes liver cirrhosis and cancer and
is a major public health concern in Kenya. However, so far no systematic review and meta …

[HTML][HTML] Hepatitis B virus genotypes and genome characteristics in China

HM Li, JQ Wang, R Wang, Q Zhao, L Li… - World journal of …, 2015 - ncbi.nlm.nih.gov
AIM: To analyze the hepatitis B virus (HBV) characters in China, as well as the correlation
between several HBV mutation and hepatitis symptoms. METHODS: A total of 1148 HBV …