Current treatment of IgA nephropathy

J Floege, T Rauen, SCW Tang - Seminars in immunopathology, 2021 - Springer
IgA nephropathy (IgAN) is the most common type of glomerulonephritis in Asia and the
Western world. In most patients, it follows an asymptomatic to oligosymptomatic course and …

IgA nephropathy

KN Lai, SCW Tang, FP Schena, J Novak… - Nature reviews Disease …, 2016 - nature.com
Abstract Globally, IgA nephropathy (IgAN) is the most common primary glomerulonephritis
that can progress to renal failure. The exact pathogenesis of IgAN is not well defined, but …

[HTML][HTML] An update on the pathogenesis and treatment of IgA nephropathy

JK Boyd, CK Cheung, K Molyneux, J Feehally… - Kidney international, 2012 - Elsevier
Over the past two decades significant progress has been made in unravelling the complex
pathogenesis of immunoglobulin A nephropathy (IgAN). Excess amounts of poorly …

[HTML][HTML] Perspectives on how mucosal immune responses, infections and gut microbiome shape IgA nephropathy and future therapies

JW He, XJ Zhou, JC Lv, H Zhang - Theranostics, 2020 - ncbi.nlm.nih.gov
Infections have been considered to play a critical role in the pathogenesis of IgA
nephropathy (IgAN) because synpharyngitic hematuria is a common feature in IgAN …

Angiotensin II blockade and renal protection

H Kobori, H Mori, T Masaki… - Current pharmaceutical …, 2013 - ingentaconnect.com
Current national guidelines have recommended the use of renin-angiotensin system
inhibitors, including angiotensin II type 1 receptor blockers (ARBs), in preference to other …

Chronic kidney disease: a new look at pathogenetic mechanisms and treatment options

D Noone, C Licht - Pediatric nephrology, 2014 - Springer
The concept of renoprotection has evolved significantly, driven by improved understanding
of the pathophysiology of chronic kidney disease (CKD) and the advent of novel treatment …

[PDF][PDF] Renin Angiotensin Aldosterone System (RAAS): its biology and drug targets for treating diabetic nephropathy.

M Zain, FR Awan - Pakistan journal of pharmaceutical sciences, 2014 - researchgate.net
Diabetes mellitus is a multifactorial disorder of hyperglycemia caused by a combination of
biochemical, molecular and genetic factors, which leads to the dysfunction of various organs …

Treatment of IgA nephropathy: evolution over half a century

J Barratt, SCW Tang - Seminars in nephrology, 2018 - Elsevier
Fifty years into the original description of IgA nephropathy, there is still no specific therapy for
this condition and general measures including blood pressure control with blockers of the …

The clinical course of IgA nephropathy after kidney transplantation and its management

S Lionaki, K Panagiotellis, C Melexopoulou… - Transplantation …, 2017 - Elsevier
Immunoglobulin (Ig) A nephropathy is one of the most common primary
glomerulonephritides worldwide causing end stage renal disease in up to 20–40% of …

Direct inhibition of plasmatic renin activity with aliskiren: a promising but under-investigated therapeutic option for non-diabetic glomerulonephritis

M Simeoni, R Nicotera, M Colao, ML Citraro… - … urology and nephrology, 2016 - Springer
Non-diabetic glomerulonephritis is a frequent cause of end-stage renal disease. The use of
renin–angiotensin–aldosterone system blockers is a fundamental therapeutic approach …