Major depressive disorder (MDD) is common, often under-treated and a leading cause of
disability and mortality worldwide. The causes of MDD remain unclear, including the role of …

Based on the known isatin-based fatty acid amide hydrolase (FAAH) inhibitor BSS-7, we
designed and synthesized two small sets (6–13 and 17–20) of N-1 and C-3 substituted isatin …

Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) are the primary
catabolic enzymes for endocannabinoids, anandamide (AEA), and 2‐arachidonoyl glycerol …

Despite a growing acceptance that withdrawal symptoms can emerge following
discontinuation of cannabis products, especially in high-intake chronic users, there are no …

Attenuating emesis elicited by both disease and medical treatments of disease remains a
critical public health challenge. Although cannabinergic medications have been used in …

Background Recently, we have reported an isatin-derived carbohydrazone, 5-chloro-N'-(6-
chloro-2-oxoindolin-3-ylidene)-2-hydroxybenzohydrazide (SIH 3) as dual nanomolar FAAH …

“Microdosing” of lysergic acid diethylamide (LSD) and other psychedelic drugs refers to an
increasingly popular practice in which individuals ingest 1/10th or less of the doses needed …

The endocannabinoid signaling system is a ubiquitous means of (sub) cellular information
transduction. Investigation of the system's molecular components and the biochemical …

Cannabinoid receptor type 1 and 2 (CB1 and CB2) are two G i/o-protein-coupled
cannabinoid receptors (CBRs), which showed promise in various conditions including pain …

Chronic secretion and exposure to IL-6 proinflammatory cytokine plays a significant role in
tumor promoting inflammation resulting in a feedback loop of persistent activation of pro …