Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

Among the four G protein–coupled receptors (H1–H4) identified as mediators of the biologic
effects of histamine, the H3 receptor (H3R) is distinguished for its almost exclusive …

The aim of this review is to provide a systematic overview on constitutively active G-protein-
coupled receptors (GPCRs), a rapidly evolving area in signal transduction research. We will …

Pharmacological receptor theory is discussed with special reference to advances made
during the past 25 years. Thus, the operational model has supplanted analysis of drug …

Since the cloning of the histamine H3 receptor cDNA in 1999 by Lovenberg and co-workers,
this histamine receptor has gained the interest of many pharmaceutical companies as a …

The histaminergic system is exclusively localized within the posterior hypothalamus with
projection to almost all the major regions of the central nervous system. Strong and …

Receptors of the of seven transmembrane spanning, heterotrimeric G protein coupled family
(GPCR) play crucial roles in regulating physiological functions and consequently are targets …

Histamine H 3 receptor pharmacology, functions and biochemistry are far from being fully
understood; however, progress is being made. Activation of this G i/G o-protein-coupled …

Histamine is a bioamine with multiple physiological activities. In the immune system, it not
only mediates the deleterious effects accompanying allergic reactions, but it acts also in a …

Histamine H3 receptor inverse agonists are known to enhance the activity of histaminergic
neurons in brain and thereby promote vigilance and cognition. 1-{3-[3-(4-Chlorophenyl) …