Emergence and developmental roles of the cerebrospinal fluid system

RM Fame, MK Lehtinen - Developmental cell, 2020 - cell.com
We summarize recent work illuminating how cerebrospinal fluid (CSF) regulates brain
function. More than a protective fluid cushion and sink for waste, the CSF is an integral CNS …

New developments in the biology of fibroblast growth factors

DM Ornitz, N Itoh - WIREs mechanisms of disease, 2022 - Wiley Online Library
The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Wnt/β-Catenin signaling promotes differentiation of ischemia-activated adult neural stem/progenitor cells to neuronal precursors

J Kriska, L Janeckova, D Kirdajova, P Honsa… - Frontiers in …, 2021 - frontiersin.org
Modulating endogenous regenerative processes may represent a suitable treatment for
central nervous system (CNS) injuries, such as stroke or trauma. Neural stem/progenitor …

On the common journey of neural cells through ischemic brain injury and Alzheimer's disease

J Kriska, Z Hermanova, T Knotek, J Tureckova… - International Journal of …, 2021 - mdpi.com
Ischemic brain injury and Alzheimer's disease (AD) both lead to cell death in the central
nervous system (CNS) and thus negatively affect particularly the elderly population. Due to …

Brain ventricular system and cerebrospinal fluid development and function: light at the end of the tube: a primer with latest insights

RM Fame, C Cortés‐Campos, HL Sive - BioEssays, 2020 - Wiley Online Library
The brain ventricular system is a series of connected cavities, filled with cerebrospinal fluid
(CSF), that forms within the vertebrate central nervous system (CNS). The hollow neural tube …

Timing as a mechanism of development and evolution in the cerebral cortex

LR Fenlon - Brain, behavior and evolution, 2022 - karger.com
One of the biggest mysteries in neurobiology concerns the mechanisms responsible for the
diversification of the brain over different time scales, ie during development and evolution …

Extracellular control of radial glia proliferation and scaffolding during cortical development and pathology

J Ferent, D Zaidi, F Francis - Frontiers in cell and developmental …, 2020 - frontiersin.org
During the development of the cortex, newly generated neurons migrate long-distances in
the expanding tissue to reach their final positions. Pyramidal neurons are produced from …

Choroid plexus: the orchestrator of long-range signalling within the CNS

K Kaiser, V Bryja - International Journal of Molecular Sciences, 2020 - mdpi.com
Cerebrospinal fluid (CSF) is the liquid that fills the brain ventricles. CSF represents not only
a mechanical brain protection but also a rich source of signalling factors modulating diverse …

Orchestrated freedom: new insights into cortical neurogenesis

A Llorca, O Marín - Current Opinion in Neurobiology, 2021 - Elsevier
Highlights•Multiple pools of progenitor cells generate neocortical pyramidal neurons during
embryonic development.•Cortical radial glial cells transit through different competence …

SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity

V Sepúlveda, F Maurelia, M González… - Fluids and Barriers of …, 2021 - Springer
Cerebrospinal fluid is a clear fluid that occupies the ventricular and subarachnoid spaces
within and around the brain and spinal cord. Cerebrospinal fluid is a dynamic signaling …