[HTML][HTML] Metal cations in G-quadruplex folding and stability
D Bhattacharyya, G Mirihana Arachchilage… - Frontiers in …, 2016 - frontiersin.org
This review is focused on the structural and physicochemical aspects of metal cation
coordination to G-Quadruplexes (GQ) and their effects on GQ stability and conformation. G …
coordination to G-Quadruplexes (GQ) and their effects on GQ stability and conformation. G …
Quadruplex nucleic acids as novel therapeutic targets
S Neidle - Journal of medicinal chemistry, 2016 - ACS Publications
Quadruplex-forming sequences are widely prevalent in human and other genomes,
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …
[HTML][HTML] Recent progress of targeted G-quadruplex-preferred ligands toward cancer therapy
A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-
rich sequences, and has profound implications for various pharmacological and biological …
rich sequences, and has profound implications for various pharmacological and biological …
DNA secondary structures: stability and function of G-quadruplex structures
ML Bochman, K Paeschke, VA Zakian - Nature Reviews Genetics, 2012 - nature.com
In addition to the canonical double helix, DNA can fold into various other inter-and
intramolecular secondary structures. Although many such structures were long thought to be …
intramolecular secondary structures. Although many such structures were long thought to be …
A guide to computational methods for G-quadruplex prediction
E Puig Lombardi, A Londoño-Vallejo - Nucleic acids research, 2020 - academic.oup.com
Guanine-rich nucleic acids can fold into the non-B DNA or RNA structures called G-
quadruplexes (G4). Recent methodological developments have allowed the characterization …
quadruplexes (G4). Recent methodological developments have allowed the characterization …
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
G-quadruplexes are four-stranded DNA structures that are over-represented in gene
promoter regions and are viewed as emerging therapeutic targets in oncology, as …
promoter regions and are viewed as emerging therapeutic targets in oncology, as …
Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids
A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …
molecule are basically designed to interact with multiple targets or to amplify its effect …
[HTML][HTML] Transcriptome-wide identification of transient RNA G-quadruplexes in human cells
Guanine-rich RNA sequences can fold into four-stranded structures, termed G-quadruplexes
(G4-RNAs), whose biological roles are poorly understood, and in vivo existence is debated …
(G4-RNAs), whose biological roles are poorly understood, and in vivo existence is debated …
Making sense of G‐quadruplex and i‐motif functions in oncogene promoters
The presence and biological importance of DNA secondary structures in eukaryotic
promoters are becoming increasingly recognized among chemists and biologists as …
promoters are becoming increasingly recognized among chemists and biologists as …
How long is too long? Effects of loop size on G-quadruplex stability
We compared here 80 different sequences containing four tracts of three guanines with
loops of variable length (between 1 and 15 bases for unmodified sequences, up to 30 for …
loops of variable length (between 1 and 15 bases for unmodified sequences, up to 30 for …