Children and adolescents and young adults (AYAs) with cancer are often treated with a
multidisciplinary approach. This includes use of radiotherapy, which is important for local …

Simple Summary Proton radiation therapy is a radiation oncology innovation expected to
produce superior health-related quality of life (HRQoL) outcomes for children with cancer …

Background Children with brain tumors are at high risk of neurocognitive decline after
radiotherapy (RT). However, there is a lack of studies on how RT doses to organs at risk …

Purpose Proton therapy (PT) is broadly accepted as the gold standard of care for pediatric
patients with cranial cancer. The superior dose distribution of PT compared to photon …

Purpose We developed and tested a novel method of creating intensity modulated proton
arc therapy (IMPAT) plans that uses computing resources similar to those for regular …

Objective: Radiobiological modelling the risks of second primary cancer (SPC) after proton
therapy (PT) for childhood cranial cancer remains largely unknown. Organ-specific dose …

Background Children and adolescents treated for a brain tumor suffer from more fatigue than
survivors of other types of childhood cancer. As tumor location might be predictive of fatigue …

Purpose To investigate stem-related differentially expressed genes (DEGs) and their
potential mechanism in pancreatic cancer cells (MIAPaCa-2) exposed to x-ray and proton …

Abstract Background and Purpose Proton therapy (PT) can reduce side effects for paediatric
cranial malignancies. Despite the high number of paediatric patients treated with PT …

Background Pituitary insufficiency is a common toxicity of cranial radiotherapy received in
childhood for central nervous system, head and neck, and hematological malignancies …