Liver fibrosis in non-alcoholic fatty liver disease: from liver biopsy to non-invasive biomarkers in diagnosis and treatment

LJM Heyens, D Busschots, GH Koek, G Robaeys… - Frontiers in …, 2021 - frontiersin.org
An increasing percentage of people have or are at risk to develop non-alcoholic fatty liver
disease (NAFLD) worldwide. NAFLD comprises different stadia going from isolated steatosis …

[HTML][HTML] Metabolic drivers of non-alcoholic fatty liver disease

KK Bence, MJ Birnbaum - Molecular metabolism, 2021 - Elsevier
Background The incidence of non-alcoholic fatty liver disease (NAFLD) is rapidly increasing
worldwide parallel to the global obesity epidemic. NAFLD encompasses a range of liver …

Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

G Lee, HJ You, JS Bajaj, SK Joo, J Yu, S Park… - Nature …, 2020 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in non-
obese individuals. Gut microbiome profiles of 171 Asians with biopsy-proven NAFLD and 31 …

[HTML][HTML] rs641738C> T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis

K Teo, KWM Abeysekera, L Adams, E Aigner… - Journal of …, 2021 - Elsevier
Background & Aims A common genetic variant near MBOAT7 (rs641738C> T) has been
previously associated with hepatic fat and advanced histology in NAFLD; however, these …

[HTML][HTML] A polygenic risk score to refine risk stratification and prediction for severe liver disease by clinical fibrosis scores

A De Vincentis, F Tavaglione, O Jamialahmadi… - Clinical …, 2022 - Elsevier
Background & Aims A polygenic risk score based on well-known genetic variants in
PNPLA3, TM6SF2, MBOAT7, and GCKR predicts hepatic fat content (polygenic risk score …

[HTML][HTML] Diagnosis and management of secondary causes of steatohepatitis

R Liebe, I Esposito, HH Bock, S Vom Dahl, J Stindt… - Journal of …, 2021 - Elsevier
The term non-alcoholic liver disease (NAFLD) was originally coined to describe hepatic fat
deposition as part of the metabolic syndrome. However, a variety of rare hereditary liver and …

[HTML][HTML] Clinical assessment and management of liver fibrosis in non-alcoholic fatty liver disease

A Campos-Murguía, A Ruiz-Margáin… - World journal of …, 2020 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is among the most frequent etiologies of cirrhosis
worldwide, and it is associated with features of metabolic syndrome; the key factor …

Toward genetic prediction of nonalcoholic fatty liver disease trajectories: PNPLA3 and beyond

M Krawczyk, R Liebe, F Lammert - Gastroenterology, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is on the verge of becoming the leading cause of
liver disease. NAFLD develops at the interface between environmental factors and inherited …

Interaction effect between NAFLD severity and high carbohydrate diet on gut microbiome alteration and hepatic de novo lipogenesis

H Kang, HJ You, G Lee, SH Lee, T Yoo, M Choi… - Gut …, 2022 - Taylor & Francis
Nonalcoholic fatty liver disease (NAFLD) is associated with high carbohydrate (HC) intake.
We investigated whether the relationship between carbohydrate intake and NAFLD is …

Genetics is of the essence to face NAFLD

M Meroni, M Longo, G Tria, P Dongiovanni - Biomedicines, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease
worldwide. It is closely related to obesity, insulin resistance (IR) and dyslipidemia so much …