Challenges in measuring and understanding biological noise
Biochemical reactions are intrinsically stochastic, leading to variation in the production of
mRNAs and proteins within cells. In the scientific literature, this source of variation is typically …
mRNAs and proteins within cells. In the scientific literature, this source of variation is typically …
HIV-1: to splice or not to splice, that is the question
A Emery, R Swanstrom - Viruses, 2021 - mdpi.com
The transcription of the HIV-1 provirus results in only one type of transcript—full length
genomic RNA. To make the mRNA transcripts for the accessory proteins Tat and Rev, the …
genomic RNA. To make the mRNA transcripts for the accessory proteins Tat and Rev, the …
A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions
INTRODUCTION Fluctuations have long been known to dynamically shape microstate
distributions in physical systems. Throughout engineering,“dithering” approaches that …
distributions in physical systems. Throughout engineering,“dithering” approaches that …
Mammalian gene expression variability is explained by underlying cell state
R Foreman, R Wollman - Molecular systems biology, 2020 - embopress.org
Gene expression variability in mammalian systems plays an important role in physiological
and pathophysiological conditions. This variability can come from differential regulation …
and pathophysiological conditions. This variability can come from differential regulation …
Engineered deletions of HIV replicate conditionally to reduce disease in nonhuman primates
Antiviral therapies with reduced frequencies of administration and high barriers to resistance
remain a major goal. For HIV, theories have proposed that viral-deletion variants, which …
remain a major goal. For HIV, theories have proposed that viral-deletion variants, which …
[HTML][HTML] Principles for the design of multicellular engineered living systems
Remarkable progress in bioengineering over the past two decades has enabled the
formulation of fundamental design principles for a variety of medical and non-medical …
formulation of fundamental design principles for a variety of medical and non-medical …
Transcriptional stochasticity as a key aspect of HIV-1 latency
A Damour, V Slaninova, O Radulescu, E Bertrand… - Viruses, 2023 - mdpi.com
This review summarizes current advances in the role of transcriptional stochasticity in HIV-1
latency, which were possible in a large part due to the development of single-cell …
latency, which were possible in a large part due to the development of single-cell …
[HTML][HTML] The life and death of RNA across temperatures
Temperature is an environmental condition that has a pervasive effect on cells along with all
the molecules and reactions in them. The mechanisms by which prototypical RNA molecules …
the molecules and reactions in them. The mechanisms by which prototypical RNA molecules …
TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV
R Matkovic, M Morel, S Lanciano, P Larrous… - Nature …, 2022 - nature.com
Abstract The Human Silencing Hub (HUSH) complex constituted of TASOR, MPP8 and
Periphilin recruits the histone methyl-transferase SETDB1 to spread H3K9me3 repressive …
Periphilin recruits the histone methyl-transferase SETDB1 to spread H3K9me3 repressive …
Dynamic nanopore long-read sequencing analysis of HIV-1 splicing events during the early steps of infection
N Nguyen Quang, S Goudey, E Ségéral, A Mohammad… - Retrovirology, 2020 - Springer
Background Alternative splicing is a key step in Human Immunodeficiency Virus type 1 (HIV-
1) replication that is tightly regulated both temporally and spatially. More than 50 different …
1) replication that is tightly regulated both temporally and spatially. More than 50 different …