Liver cancers cause a high rate of death worldwide and hepatocellular carcinoma (HCC) is
considered as the most common primary liver cancer. HCC remains a challenging disease …

The liver plays a key role in sensing nutritional and hormonal inputs to maintain metabolic
homeostasis. Recent studies into pre-mRNA splicing and alternative splicing (AS) and their …

Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer, but a
comprehensive description of its genomic landscape is lacking. We report the whole …

Ovarian cancer is resistant to immune checkpoint blockade (ICB) treatment. Combination of
targeted therapy and immunotherapy is a promising strategy for ovarian cancer treatment …

Splicing factors play a crucial role in the initiation and development of various human
cancers. SNRPB, a core spliceosome component, regulates pre-mRNA alternative splicing …

Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, requiring
novel treatments to target both cancer cells and cancer stem cells (CSCs). Altered splicing is …

Background Glioblastoma is one of the most devastating cancer worldwide based on its
locally aggressive behavior and because it cannot be cured by current therapies. Defects in …

ONCOFIT is a randomized clinical trial with a two-arm parallel design aimed at determining
the influence of a multidisciplinary Prehabilitation and Postoperative Program (PPP) on post …

This study aimed to investigate the expression of SF3B1 in non-small cell lung cancer, and
its clinical significance, biological function, and molecular mechanisms. SF3B1 mRNA and …

Hepatocellular carcinoma (HCC) pathogenesis is associated with alterations in splicing
machinery components (spliceosome and splicing factors) and aberrant expression of …